Background DNA methylation is a heritable epigenetic mark, enabling stable but reversible
gene repression. In mammalian cells, DNA methyltransferases (DNMTs) are responsible for …

DNA methylation is a covalent biochemical modification controlling chromatin structure and
gene expression. Exercise elicits gene expression changes that trigger structural and …

Age-related tissue alterations have been associated with a decline in stem cell number and
function. Although increased cell-to-cell variability in transcription or epigenetic marks has …

DNA methylation is an essential epigenetic mark whose role in gene regulation and its
dependency on genomic sequence and environment are not fully understood. In this study …

Despite existing reports on differential DNA methylation in type 2 diabetes (T2D) and
obesity, our understanding of its functional relevance remains limited. Here we show the …

The methylome and transcriptome signatures following exercise that are physiologically and
metabolically relevant to sporting contexts such as team sports or health prescription …

Epigenomic regulation of the transcriptome by DNA methylation and posttranscriptional
gene silencing by miRNAs are potential environmental modulators of skeletal muscle …

Increased age, BMI and HbA1c levels are risk factors for several non-communicable
diseases. However, the impact of these factors on the genome-wide DNA methylation …

Skeletal muscle cells have served as a paradigm for understanding mechanisms leading to
cellular differentiation. The proliferation and differentiation of muscle precursor cells require …

Histone lysine methylation, as one of the most important factors in transcriptional regulation,
is associated with a various physiological conditions. Using a bioinformatics search, we …