The genetic architecture of pain intensity in a sample of 598,339 US veterans

H Kranzler, S Toikumo, R Vickers-Smith, Z Jinwala… - 2023 - researchsquare.com
Chronic pain is a common problem, with more than one-fifth of adult Americans reporting
pain daily or on most days. It adversely affects quality of life and imposes substantial …

[HTML][HTML] The genetic architecture of pain intensity in a sample of 598,339 US veterans

S Toikumo, R Vickers-Smith, Z Jinwala, H Xu, D Saini… - medRxiv, 2023 - ncbi.nlm.nih.gov
Chronic pain is a common problem, with more than one-fifth of adult Americans reporting
pain daily or on most days. It adversely affects quality of life and imposes substantial …

9. THE GENETIC ARCHITECTURE OF PAIN INTENSITY IN THE MILLION VETERAN PROGRAM

S Toikumo, R Vickers-Smith, Z Jinwala, H Xu… - European …, 2023 - Elsevier
Background Chronic pain is a common problem, with more than one-fifth of adult Americans
reporting pain daily or on most days. It adversely affects quality of life and imposes …

the genetic architecture of pain intensity

S Toikumo, HR Kranzler - nature.com
Chronic pain is common, with more than one in five adult Americans reporting having pain
daily or on most days. A multi-ancestry genomic analysis in 598,339 military veterans in the …

A multi-ancestry genetic study of pain intensity in 598,339 veterans

S Toikumo, R Vickers-Smith, Z Jinwala, H Xu, D Saini… - Nature Medicine, 2024 - nature.com
Chronic pain is a common problem, with more than one-fifth of adult Americans reporting
pain daily or on most days. It adversely affects the quality of life and imposes substantial …

[HTML][HTML] Genome wide association joint analysis reveals 99 risk loci for pain susceptibility and pleiotropic relationships with psychiatric, metabolic, and immunological …

E Mocci, K Ward, JA Perry, A Starkweather… - PLoS …, 2023 - journals.plos.org
Chronic pain is at epidemic proportions in the United States, represents a significant burden
on our public health system, and is coincident with a growing opioid crisis. While numerous …

[PDF][PDF] A shared genetic signature for common chronic pain conditions and its impact on biopsychosocial traits

RMJ de Zoete PhD - scholar.archive.org
Background: The multifactorial heterogenous nature of chronic pain with its multiple
comorbidities presents a formidable challenge in disentangling the aetiology underlying …

[HTML][HTML] A shared genetic signature for common chronic pain conditions and its impact on biopsychosocial traits

SF Farrell, PF Kho, M Lundberg, AI Campos… - The Journal of …, 2023 - Elsevier
The multiple comorbidities & dimensions of chronic pain present a formidable challenge in
disentangling its aetiology. Here, we performed genome-wide association studies of 8 …

GWAS meta-analysis reveals dual neuronal and immunological etiology for pain susceptibility

E Mocci, K Ward, SG Dorsey, SA Ament - medRxiv, 2021 - medrxiv.org
Chronic pain is at epidemic proportions in the United States, represents a significant burden
on our public health system and is coincident with a growing opioid crisis. While numerous …

Are we getting anywhere in human pain genetics?

JS Mogil - Pain, 2009 - journals.lww.com
Over the past decade, the ready availability of non-invasive DNA sampling, genotyping
cores and bioinformatics expertise has allowed pain researchers with access to patient …