Recent candidate gene studies have identified and replicated the first associations between
several common polymorphisms and pain severity in humans. Moreover, human studies in …

Quite a few genetic polymorphisms have been identified that associate with painful medical
conditions. There is remarkable variability in the amount pain that different people …

Pharmacotherapy, which remains the cornerstone of chronic pain management, includes
analgesics such as nonsteroidal anti-inflammatory drugs (NSAIDs), the more potent opioids …

Purpose This paper summarizes current knowledge of pain-related and analgesic-related
pathways as well as genetic variations involved in pain perception and management …

Deep pain is classified into 2 general categories, ie, nociceptive and neuropathic,
depending on the type of neural injury. In many cases, specific tissue damage, eg, due to …

Chronic musculoskeletal pain affects all aspects of human life. However, mechanisms of its
genetic control remain poorly understood. Genetic studies of pain are complicated by the …

Individuals suffering from chronic pain develop substance use disorders (SUDs) more often
than others. Understanding the shared genetic influences underlying the comorbidity …

Background: Chronic pain affects one fifth of American adults, contributing significant public
health burden. Chronic pain mechanisms can be further understood through investigating …

Numerous genome-wide association studies have identified risk genes for chronic pain, yet
the mechanisms by which genetic variants modify susceptibility have remained elusive. We …

Pain is an immense clinical and societal challenge, and the key to understanding and
treating it is variability. Robust interindividual differences are consistently observed in pain …