Precision medicine: the emerging approach to the chronic pain patient
Chronic pain is a major public health issue. Its management mandates a multidisciplinary
clinical assessment. Over the past decades, the individual variation in response to analgesic …
clinical assessment. Over the past decades, the individual variation in response to analgesic …
[HTML][HTML] Genetic and environmental risk for chronic pain and the contribution of risk variants for major depressive disorder: a family-based mixed-model analysis
Background Chronic pain is highly prevalent and a significant source of disability, yet its
genetic and environmental risk factors are poorly understood. Its relationship with major …
genetic and environmental risk factors are poorly understood. Its relationship with major …
The consequence of concomitantly present functional genetic variants for the identification of functional genotype–phenotype associations in pain
J Lötsch, K Fluehr, T Neddermayer… - Clinical …, 2009 - Wiley Online Library
Genetics‐based personalized approaches to pain management have received a setback
because of the nonreproducibility of functional genetic associations such as the pain …
because of the nonreproducibility of functional genetic associations such as the pain …
Pharmacogenomics of Opioid Treatment for Pain Management
S Howes, AR Cloutet, J Kweon, TL Powell… - … in Drug Discovery and …, 2022 - Springer
Pain affects approximately 100 million Americans. Pain harms quality of life and costs
patients billions of dollars per year. Clinically, nonpharmacologic and pharmacologic …
patients billions of dollars per year. Clinically, nonpharmacologic and pharmacologic …
[HTML][HTML] Development of an AmpliSeqTM Panel for Next-Generation Sequencing of a Set of Genetic Predictors of Persisting Pain
D Kringel, MA Kaunisto, C Lippmann, E Kalso… - Frontiers in …, 2018 - frontiersin.org
Background: Many gene variants modulate the individual perception of pain and possibly
also its persistence. The limited selection of single functional variants is increasingly being …
also its persistence. The limited selection of single functional variants is increasingly being …
Pharmacogenetics of pain and analgesia
MT Smith, A Muralidharan - Clinical genetics, 2012 - Wiley Online Library
Pain severity ratings and the analgesic dosing requirements of patients with apparently
similar pain conditions may differ considerably between individuals. Contributing factors …
similar pain conditions may differ considerably between individuals. Contributing factors …
Genetic influence on nociceptive processing in the human brain—A twin study
Nociceptive processing in the human brain is complex and involves several brain structures
and varies across individuals. Determining the structures that contribute to interindividual …
and varies across individuals. Determining the structures that contribute to interindividual …
Heritability of musculoskeletal pain and pain sensitivity phenotypes: 2 generations of the Raine Study
There is a need to better understand biological factors that increase the risk of persistent
musculoskeletal (MSK) pain and heightened pain sensitivity. Knowing the heritability (how …
musculoskeletal (MSK) pain and heightened pain sensitivity. Knowing the heritability (how …
A step towards understanding disparities–linking race, ancestry, epigenetics and pain
V Chidambaran, TB Mersha - Epigenomics, 2021 - Taylor & Francis
The 2016 Global Burden of Disease study reaffirmed that chronic pain and pain-related
diseases are a leading cause of disability [1]. Differences in risk and susceptibility to pain …
diseases are a leading cause of disability [1]. Differences in risk and susceptibility to pain …