Avasopasem manganese (AVA or GC4419), a selective superoxide dismutase mimetic, is in
a phase 3 clinical trial (NCT03689712) as a mitigator of radiation-induced mucositis in head …

Toxicities associated with radiation therapy are common, symptomatically devastating, and
costly. The best chance to effectively mitigate radiation-associated normal tissue side effects …

While radiotherapy is a widely used treatment for many types of human cancer, problems of
radio-resistance and side effects remain. Side effects induced by ionizing radiation (IR) arise …

Purpose: M40403 is a small-molecule superoxide dismutase mimetic that has shown
efficacy in animal model disease states in which superoxide anions are thought to play a key …

Symptomatic normal tissue injury is a common side effect following definitive therapeutic
radiation and chemotherapy treatment for a variety of malignancies. These cancer therapy …

Lung cancer, together with head and neck cancer, accounts for more than one-fourth of
cancer deaths worldwide. New, non-toxic therapeutic approaches are needed. High-dose IV …

Abstract Arsenic trioxide (As2O3) is an effective therapeutic against acute promyelocytic
leukemia and certain solid tumors. Because As2O3 inhibits mitochondrial respiration in …

We hypothesized that inhibitors of peroxide removal, such as BCNU, an indirect inhibitor of
glutathione peroxidase (GPx), and 3-amino-1, 2, 4-triazole (AT), a direct inhibitor of catalase …

Auranofin (AF) is an anti-arthritic drug considered for combined chemotherapy due to its
ability to impair the redox homeostasis in tumor cells. In this study, we asked whether AF …

Salen Mn complexes, including EUK-134, EUK-189 and a newer cyclized analog EUK-207,
are synthetic SOD/catalase mimetics that have beneficial effects in many models of oxidative …