The role of neurotransmitters and neuropeptides in Parkinson's disease: implications for therapy

Y Gilgun-Sherki, M Hellmann, E Melamed… - Drugs Future, 2004 - access.portico.org
Parkinson's disease is a progressive neurodegenerative disease of the basal ganglia.
Pathologically, it is characterized by continuous dopaminergic cell loss in the nigrostriatal …

Classical Neurotransmitters and Neuropeptides Involved in Parkinson's Disease: Focus on Anti-Parkinsonian Drugs

FM Werner, R Coveñas - Current Drug Therapy, 2015 - ingentaconnect.com
In Parkinson's disease a dopaminergic/cholinergic and a GABAergic/glutaminergic
neurotransmitter imbalance occurs in the extrapyramidal system. Here, in this system, we …

Involvement of non-dopaminergic pathways in Parkinson's disease: pathophysiology and therapeutic implications

AM Bonnet - CNS drugs, 2000 - Springer
Parkinson's disease is primarily characterised by degeneration of the nigrostriatal
dopaminergic pathways in the basal ganglia. However, non-dopaminergic …

Neurotransmission in Parkinson's disease: beyond dopamine

P Barone - European journal of neurology, 2010 - Wiley Online Library
Parkinson's disease (PD) is most frequently associated with characteristic motor symptoms
that are known to arise with degeneration of dopaminergic neurons. However, patients with …

[PDF][PDF] The dopaminergic and non-dopaminergic features of Parkinson's disease

CW Olanow, F Stocchi, AE Lang - Parkinson's Disease, 2011 - medien.ubitweb.de
Parkinson's disease (PD) is a common age-related neurodegenerative disorder, second
only to Alzheimer's disease (AD). It is named in honor of James Parkinson, who provided a …

Parkinson's disease: Mechanisms, translational models and management strategies

C Raza, R Anjum - Life sciences, 2019 - Elsevier
Parkinson's disease is a progressive neurodegenerative disorder. The classical motor
symptoms include resting tremors, bradykinesia, rigidity and postural instability and are …

Advances in the pharmacological treatment of Parkinson's disease: targeting neurotransmitter systems

L Brichta, P Greengard, M Flajolet - Trends in neurosciences, 2013 - cell.com
For several decades, the dopamine precursor levodopa has been the primary therapy for
Parkinson's disease (PD). However, not all of the motor and non-motor features of PD can …

[HTML][HTML] Non-dopaminergic systems in Parkinson's disease

C Miguelez, P De Deurwaerdère… - Frontiers in …, 2020 - frontiersin.org
This collection presents an array of articles addressing the non-dopaminergic mechanisms
in Parkinson's disease (PD). The dopaminergic system has been the main focus for almost …

[PDF][PDF] Classical neurotransmitters and neuropeptides involved in Parkinson's Disease: A multi-neurotransmitter system

FM Werner, R Coveñas - Journal of Cytology & Histology, 2014 - pdfs.semanticscholar.org
Parkinson's disease is a neurodegenerative disease with motor and non-motor symptoms. In
Parkinson's disease, a neurotransmitter imbalance occurs in the extrapyramidal system with …

A recent update on drugs and alternative approaches for parkinsonism

S Kispotta, D Das, SK Prusty - Neuropeptides, 2024 - Elsevier
Parkinson's disease, often known as PD, is a more common age-related neurological
disorder that affects a huge number of older adults worldwide. Parkinson's disease is …