The VraS/VraR two-component regulatory system required for oxacillin resistance in community-acquired methicillin-resistant Staphylococcus aureus
S Boyle-Vavra, S Yin, RS Daum - FEMS microbiology letters, 2006 - academic.oup.com
Methicillin/oxacillin (Oxa) resistance in Staphylococcus aureus is primarily mediated by the
acquired penicillin-binding protein (PBP2a) encoded by mecA. PBP2a acts together with …
acquired penicillin-binding protein (PBP2a) encoded by mecA. PBP2a acts together with …
Identification and Phenotypic Characterization of a β-Lactam-Dependent, Methicillin-Resistant Staphylococcus aureus Strain
F Goldstein, J Perutka, A Cuirolo, K Plata… - Antimicrobial agents …, 2007 - Am Soc Microbiol
Methicillin resistance in Staphylococcus aureus is primarily mediated by the acquired
penicillin-binding protein PBP 2a, which is encoded by mecA. PBP 2a acts together with …
penicillin-binding protein PBP 2a, which is encoded by mecA. PBP 2a acts together with …
Evolving MRSA: High-level β-lactam resistance in Staphylococcus aureus is associated with RNA Polymerase alterations and fine tuning of gene expression
VV Panchal, C Griffiths, H Mosaei, B Bilyk… - PLoS …, 2020 - journals.plos.org
Most clinical MRSA (methicillin-resistant S. aureus) isolates exhibit low-level β-lactam
resistance (oxacillin MIC 2–4 μg/ml) due to the acquisition of a novel penicillin binding …
resistance (oxacillin MIC 2–4 μg/ml) due to the acquisition of a novel penicillin binding …
Identification and characterization of mutations responsible for the β-lactam resistance in oxacillin-susceptible mecA-positive Staphylococcus aureus
T Boonsiri, S Watanabe, XE Tan, K Thitiananpakorn… - Scientific Reports, 2020 - nature.com
Staphylococcus aureus strains that are susceptible to the β-lactam antibiotic oxacillin
despite carrying mecA (OS-MRSA) cause serious clinical problems globally because of their …
despite carrying mecA (OS-MRSA) cause serious clinical problems globally because of their …
VraSR Two-Component Regulatory System Contributes to mprF-Mediated Decreased Susceptibility to Daptomycin in In Vivo-Selected Clinical Strains of Methicillin …
S Mehta, AX Cuirolo, KB Plata, S Riosa… - Antimicrobial agents …, 2012 - Am Soc Microbiol
Daptomycin (DAP) is a new class of cyclic lipopeptide antibiotic highly active against
methicillin-resistant Staphylococcus aureus (MRSA) infections. Proposed mechanisms …
methicillin-resistant Staphylococcus aureus (MRSA) infections. Proposed mechanisms …
Role of mecA transcriptional regulation in the phenotypic expression of methicillin resistance in Staphylococcus aureus
DM Niemeyer, MJ Pucci, JA Thanassi… - Journal of …, 1996 - Am Soc Microbiol
The gene required for methicillin resistance in staphylococci, mecA, encodes the low-affinity
penicillin-binding protein 2a (PBP2a). Transcriptional regulation of mecA is accomplished in …
penicillin-binding protein 2a (PBP2a). Transcriptional regulation of mecA is accomplished in …
Redefining the Role of the β-Lactamase Locus in Methicillin-Resistant Staphylococcus aureus: β-Lactamase Regulators Disrupt the MecI-Mediated Strong Repression on mecA …
P Arêde, J Ministro, DC Oliveira - Antimicrobial agents and …, 2013 - Am Soc Microbiol
In response to β-lactam chemotherapy, Staphylococcus aureus has acquired two resistance
determinants: blaZ, coding for β-lactamase, which confers resistance to penicillins only, and …
determinants: blaZ, coding for β-lactamase, which confers resistance to penicillins only, and …
The Global Regulon sarA Regulates β-Lactam Antibiotic Resistance in Methicillin-Resistant Staphylococcus aureus In Vitro and in Endovascular Infections
Background. The global regulator sarA modulates virulence of methicillin-resistant
Staphylococcus aureus (MRSA) via regulation of principal virulence factors (eg, adhesins …
Staphylococcus aureus (MRSA) via regulation of principal virulence factors (eg, adhesins …
Methicillin-Resistance in Staphylococcus aureus Is Not Affected by the Overexpression in Trans of the mecA Gene Repressor: A Surprising Observation
DC Oliveira, H De Lencastre - PLoS One, 2011 - journals.plos.org
Methicillin-resistant Staphylococcus aureus (MRSA) is intrinsically cross-resistant to virtually
all β-lactam antibiotics. The central determinant for the MRSA phenotype is the mecA gene …
all β-lactam antibiotics. The central determinant for the MRSA phenotype is the mecA gene …
sarA inactivation reduces vancomycin-intermediate and ciprofloxacin resistance expression by Staphylococcus aureus
R Lamichhane-Khadka, SA Cantore, JT Riordan… - International journal of …, 2009 - Elsevier
It is known that multiple genome-wide transcriptional changes often accompany the
development of antimicrobial resistance and occur in response to challenge with …
development of antimicrobial resistance and occur in response to challenge with …