Tumor initiation and progression are somatic evolutionary processes driven by the
accumulation of genetic alterations, some of which confer selective fitness advantages to the …

Most (if not all) tumors emerge and progress under a strong evolutionary pressure imposed
by trophic, metabolic, immunological, and therapeutic factors. The relative impact of these …

The role of genetic mutations in cancer is indisputable: They are a key source of tumor
heterogeneity and drive its evolution to malignancy. But, the success of these new mutant …

The transformation of normal cells into cancer cells and maintenance of the malignant state
and phenotypes are associated with genetic and epigenetic deregulations, altered cellular …

Cancer is driven by the somatic evolution of cell lineages that have escaped controls on
replication and by the population-level evolution of genes that influence cancer risk. We …

High-throughput sequencing can be used to measure changes in tumor composition across
space and time. Specifically, comparisons of pre-and post-treatment samples can reveal the …

Cancer progression is an evolutionary process. During this process, evolving cancer cell
populations encounter restrictive ecological niches within the body, such as the primary …

Transcriptional heterogeneity among malignant cells of a tumor has been studied in
individual cancer types and shown to be organized into cancer cell states; however, it …

Genetic and epigenetic changes in cancer cells are typically divided into 'drivers' and
'passengers'. Drug development strategies target driver mutations, but inter-and intratumoral …

Cancer is a major cause of global mortality underpinned by genomic and epigenomic
derangements. Here, we highlight the importance of multimodal data integration in …