Amyotrophic lateral sclerosis (ALS) is a fatal progressive central nervous system disorder
affecting the upper and lower motor neurons. It is important to study the features of the …

Objectives To explore the sensitivity of potential DTI-based biomarkers in detecting
microstructural changes for whole-brain white matter in early stage amyotrophic lateral …

Background Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease
characterized by loss of upper and lower motor neurons. There is a need for an imaging …

Even though neuroimaging and clinical studies indicate that amyotrophic lateral sclerosis
(ALS) manifests with distinct clinical phenotypes, no objective test exists to assess upper …

Background Amyotrophic lateral sclerosis (ALS) is a fatal, rapidly progressive
neurodegenerative disease that mainly affects the motor system. A number of potentially …

Background and objective The neuropathology of amyotrophic lateral sclerosis (ALS)
follows a regional distribution pattern in the brain with four stages. Using diffusion tensor …

Background This study was performed to assess changes in diffusion tensor imaging (DTI)
over time in patients with amyotrophic lateral sclerosis (ALS). Methods We performed DTI in …

Neuroimaging allows investigating the extent of neurological systems degeneration in
amyotrophic lateral sclerosis (ALS). Advanced MRI methods can detect changes related to …

Objective: The potential of magnetic resonance imaging (MRI) as a technical biomarker for
cerebral microstructural alterations in neurodegenerative diseases is under investigation. In …

Objective Reliable biomarkers for amyotrophic lateral sclerosis (ALS) are needed, given the
clinical heterogeneity of the disease. Here, we provide proof‐of‐concept for using …