Diffusion tensor imaging (DTI) allows the in vivo imaging of pathological white matter
alterations, either with unbiased voxel-wise or hypothesis-guided tract-based analysis …

Objective The corticospinal tract (CST) reveals progressive microstructural alterations in ALS
measurable by DTI. The aim of this study was to evaluate fractional anisotropy (FA) along …

The relevance of the study lies in the need to improve the diagnosis of amyotrophic lateral
sclerosis (ALS) by utilizing diffusion tensor imaging (DTI) obtained from conventional 1.5 …

Our objective was to explore the value of additional MR contrasts in elucidating the
decrease in fractional anisotropy (FA) as has been observed in the corticospinal tracts (CST) …

Objective Neuropathological studies in amyotrophic lateral sclerosis (ALS) have shown a
dissemination in a regional sequence in four anatomically defined patterns. The aim of this …

Background. Research on amyotrophic lateral sclerosis (ALS) reveals that the disorder is not
restricted to motor neurons. Objectives. This neuroimaging study aimed to investigate the …

Objective To assess the relationship between clinically assessed Upper Motor Neuron
(UMN) disease in Amyotrophic Lateral Sclerosis (ALS) and local diffusion alterations …

Upper motor neuron (UMN) dysfunction in Amyotrophic Lateral Sclerosis (ALS) is not easy to
identify clinically: Diffusion Tensor Imaging (DTI) and single-voxel Magnetic Resonance …

Introduction: In the last decade, multiparametric magnetic resonance imaging (MRI) has
achieved tremendous advances in applications to amyotrophic lateral sclerosis (ALS) to …

Background: There is currently no definite neuroimaging test to detect amyotrophic lateral
sclerosis (ALS), which leads to significant delay in diagnosis, particularly if one takes into …