Objective To evaluate MRI-based parameters as biomarkers of Amyotrophic Lateral
Sclerosis (ALS) progression. Methods Twenty-seven patients and 27 controls performed two …

Background The criteria for assessing upper motor neuron pathology in pure lower motor
neuron disease (LMND) still remain a major issue of debate with respect to the clinical …

Therapeutic development in amyotrophic lateral sclerosis (ALS) is hampered by the lack of
suitable biomarkers that might be sensitive to spatial and temporal patterns of …

Objective Using magnetic resonance (MR) high angular resolution diffusion imaging
(HARDI), we aimed at revealing possible microstructural alterations in the early stage of …

The aim of this work was to investigate white-matter microstructural changes within and
outside the corticospinal tract in classical amyotrophic lateral sclerosis (ALS) and in lower …

Amyotrophic lateral sclerosis is a chronic progressive neurodegenerative disease of
unknown etiology. It selectively affects both upper and lower motor neurons. Nowadays …

Previous diffusion tensor imaging (DTI) studies have shown white matter pathology in
amyotrophic lateral sclerosis (ALS), predominantly in the motor pathways. Further these …

The diagnosis of amyotrophic lateral sclerosis (ALS) remains a clinical diagnosis. It is based
on the combination of both upper and lower motor neuron signs in the neurologic …

BACKGROUND AND PURPOSE: The previous studies described phenotype-associated
imaging findings in amyotrophic lateral sclerosis (ALS) with a prior categorization of patients …

In patients with ALS, conventional MR imaging is frequently noninformative, and its use has
been restricted to excluding other conditions that can mimic ALS. Conversely, the extensive …