Autoimmune diseases affect 5–9% of the world's population. It is now known that genetics
play a relatively small part in the pathophysiology of autoimmune disorders in general, and …

The incidence of autoimmunity is growing rapidly worldwide. Many epidemiological studies
have found environmental factors, such as toxic chemicals (persistent organic pollutants …

While the T and B lymphocyte repertoires are designed to be able to recognize foreign
antigen (pathogens) to protect the host, significant portions of these repertoires can …

Autoimmune diseases have registered an alarming rise worldwide in recent years.
Accumulated evidence indicates that the immune system′ s ability to distinguish self from …

Currently, studies have shown that genetic predisposition accounts for approximately thirty
percent of all autoimmune diseases. The rest, 70 percent, are due to environmental factors …

Autoimmune diseases, which comprise over 80 clinically distinct conditions, are
characterized by the presence of autoantibodies or autoreactive T cells directed against self …

Autoimmune diseases include 80 or more complex disorders characterized by self-reactive,
pathologic immune responses in which genetic susceptibility is largely insufficient to …

Susceptibility to autoimmune diseases is dependent on multigenic inheritance,
environmental factors, and stochastic events. Although there has been substantial progress …

This monograph is based on the workshop" Linking Environmental Agents and Autoimmune
Diseases" held at the National Institute of Environmental Health Sciences held 1-3 …

The mechanisms leading to autoimmune diseases remain largely unknown despite
numerous lines of experimental inquiry and epidemiological evidence. The growing number …