Genetics of dilated cardiomyopathy

S Kärkkäinen, K Peuhkurinen - Annals of medicine, 2007 - Taylor & Francis
Dilated cardiomyopathy (DCM) is a myocardial disease characterized by dilatation and
impaired systolic function of the left or both ventricles. The etiology of DCM is multifactorial …

Evidence-based assessment of genes in dilated cardiomyopathy

E Jordan, L Peterson, T Ai, B Asatryan, L Bronicki… - Circulation, 2021 - Am Heart Assoc
Background: Each of the cardiomyopathies, classically categorized as hypertrophic
cardiomyopathy, dilated cardiomyopathy (DCM), and arrhythmogenic right ventricular …

Reevaluating the genetic contribution of monogenic dilated cardiomyopathy

F Mazzarotto, U Tayal, RJ Buchan, W Midwinter… - Circulation, 2020 - Am Heart Assoc
Background: Dilated cardiomyopathy (DCM) is genetically heterogeneous, with> 100
purported disease genes tested in clinical laboratories. However, many genes were …

Investigation of a family with autosomal dominant dilated cardiomyopathy defines a novel locus on chromosome 2q14-q22

M Jung, I Poepping, A Perrot, AE Ellmer… - The American Journal of …, 1999 - cell.com
Dilated cardiomyopathy (DCM) is a leading cause of heart failure and the most frequent
indication for heart transplantation in young patients. Probably> 25% of DCM cases are of …

Atlas of the clinical genetics of human dilated cardiomyopathy

J Haas, KS Frese, B Peil, W Kloos, A Keller… - European heart …, 2015 - academic.oup.com
Aim Numerous genes are known to cause dilated cardiomyopathy (DCM). However, until
now technological limitations have hindered elucidation of the contribution of all clinically …

Frequency, penetrance, and variable expressivity of dilated cardiomyopathy–associated putative pathogenic gene variants in UK Biobank participants

RA Shah, B Asatryan, G Sharaf Dabbagh, N Aung… - Circulation, 2022 - Am Heart Assoc
Background: There is a paucity of data regarding the phenotype of dilated cardiomyopathy
(DCM) gene variants in the general population. We aimed to determine the frequency and …

Implications of genetic testing in dilated cardiomyopathy

JAJ Verdonschot, MR Hazebroek… - Circulation: Genomic …, 2020 - Am Heart Assoc
Background: Genetic analysis is a first-tier test in dilated cardiomyopathy (DCM). Electrical
phenotypes are common in genetic DCM, but their exact contribution to the clinical course …

Dilated cardiomyopathy in the era of precision medicine: latest concepts and developments

N Orphanou, E Papatheodorou, A Anastasakis - Heart failure reviews, 2022 - Springer
Dilated cardiomyopathy (DCM) is an umbrella term entailing a wide variety of genetic and
non-genetic etiologies, leading to left ventricular systolic dysfunction and dilatation, not …

Genetic causes of dilated cardiomyopathy

L Mestroni, F Brun, A Spezzacatene, G Sinagra… - Progress in pediatric …, 2014 - Elsevier
Dilated cardiomyopathy is a disease of the myocardium characterized by left ventricular
dilatation and/or dysfunction, affecting both adult and pediatric populations. Almost half of …

Clinical and genetic issues in familial dilated cardiomyopathy

EL Burkett, RE Hershberger - Journal of the American College of …, 2005 - jacc.org
Idiopathic dilated cardiomyopathy (IDC) is characterized by left ventricular dilatation and
systolic dysfunction after known causes have been excluded. Idiopathic dilated …