Frequency and phenotypes of familial dilated cardiomyopathy

E Grünig, JA Tasman, H Kücherer, W Franz… - Journal of the American …, 1998 - jacc.org
Objectives. This prospective study was performed to analyze the frequency and clinical
characteristics of idiopathic dilated cardiomyopathy (DCM). Background. Despite several …

[HTML][HTML] Genetics and genomics of dilated cardiomyopathy and systolic heart failure

U Tayal, S Prasad, SA Cook - Genome medicine, 2017 - Springer
Heart failure is a major health burden, affecting 40 million people globally. One of the main
causes of systolic heart failure is dilated cardiomyopathy (DCM), the leading global …

Evaluating pathogenicity of rare variants from dilated cardiomyopathy in the exome era

N Norton, PD Robertson, MJ Rieder… - Circulation …, 2012 - Am Heart Assoc
Background—Human exome sequencing is a recently developed tool to aid in the discovery
of novel coding variants. Now broadly applied, exome sequencing data sets provide a novel …

Dilated cardiomyopathy: a review

A Luk, E Ahn, GS Soor, J Butany - Journal of clinical pathology, 2009 - jcp.bmj.com
Dilated cardiomyopathy (DCM) is a common cardiac diagnosis that may result as a
consequence of a variety of pathologies. The differential diagnosis remains quite broad …

Dilated cardiomyopathy: from epidemiologic to genetic phenotypes: a translational review of current literature

D Reichart, C Magnussen, T Zeller… - Journal of internal …, 2019 - Wiley Online Library
Dilated cardiomyopathy (DCM) is characterized by left ventricular dilatation and,
consecutively, contractile dysfunction. The causes of DCM are heterogeneous. DCM often …

Update 2011: clinical and genetic issues in familial dilated cardiomyopathy

RE Hershberger, JD Siegfried - Journal of the American College of …, 2011 - jacc.org
A great deal of progress has recently been made in the discovery and understanding of the
genetics of familial dilated cardiomyopathy (FDC). A consensus has emerged that with a …

Diagnosis, prevalence, and screening of familial dilated cardiomyopathy

ME Sweet, MRG Taylor, L Mestroni - Expert opinion on orphan …, 2015 - Taylor & Francis
Introduction: Dilated cardiomyopathy (DCM) is the most common cardiomyopathy and
occurs often in families. As an inherited disease, understanding the significance of …

Genetics of dilated cardiomyopathy: practical implications for heart failure management

AN Rosenbaum, KE Agre, NL Pereira - Nature Reviews Cardiology, 2020 - nature.com
Given the global burden of heart failure, strategies to understand the underlying cause or to
provide prognostic information are critical to reducing the morbidity and mortality associated …

[HTML][HTML] Targeted next-generation sequencing of candidate genes reveals novel mutations in patients with dilated cardiomyopathy

Y Zhao, Y Feng, YM Zhang… - International …, 2015 - spandidos-publications.com
Dilated cardiomyopathy (DCM) is a major cause of sudden cardiac death and heart failure,
and it is characterized by genetic and clinical heterogeneity, even for some patients with a …

[HTML][HTML] Many roads lead to a broken heart: the genetics of dilated cardiomyopathy

J Schönberger, CE Seidman - The American Journal of Human Genetics, 2001 - cell.com
Heart disease is a major cause of morbidity and premature mortality in the United States.
Cardiovascular disease affects 159 million Americans, ranks first among all diagnostic …