[HTML][HTML] Long-Lasting Virus-Specific T Cell Response with Divergent Features in Self-Resolved and Chronic Hepatitis C Virus Patients 35 Years Postinfection

W Ji, M Zhao, J Zhou, H Zheng, N Li, B Han, W Yin… - …, 2022 - journals.aai.org
Although recognized as a curable disease, the persistence of hepatitis C virus (HCV) in
chronically infected patients remains a great burden for public health. T cell immune …

Immune Activation Induces Telomeric DNA Damage and Promotes Short‐Lived Effector T Cell Differentiation in Chronic HCV Infection

LN Nguyen, LNT Nguyen, J Zhao, M Schank… - …, 2021 - Wiley Online Library
Background and Aims Hepatitis C virus (HCV) leads to a high rate of chronic infection and T
cell dysfunction. Although it is well known that chronic antigenic stimulation is a driving force …

[HTML][HTML] Hepatitis C virus–specific CD4+ T cell phenotype and function in different infection outcomes

DY Chen, D Wolski, J Aneja… - The Journal of …, 2020 - Am Soc Clin Investig
CD4+ T cell failure is a hallmark of chronic hepatitis C virus (HCV) infection. However, the
mechanisms underlying the impairment and loss of virus-specific CD4+ T cells in persisting …

Clinical responders to antiviral therapy of chronic HCV infection show elevated antiviral CD4+ and CD8+ T‐cell responses

V Pillai, WM Lee, DL Thiele… - Journal of viral …, 2007 - Wiley Online Library
Chronic hepatitis C virus (HCV) infection is characterized by attenuated antiviral T‐cell
responses, making their detection and characterization a technological challenge. The role …

[HTML][HTML] HCV-specific T cell responses during and after chronic HCV infection

H Luxenburger, C Neumann-Haefelin, R Thimme… - Viruses, 2018 - mdpi.com
Hepatitis C virus (HCV)-specific T cell responses are closely linked to the clinical course of
infection. While T cell responses in self-limiting infection are typically broad and multi …

Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence

J Schulze zur Wiesch, D Ciuffreda… - Journal of Experimental …, 2012 - rupress.org
Vigorous proliferative CD4+ T cell responses are the hallmark of spontaneous clearance of
acute hepatitis C virus (HCV) infection, whereas comparable responses are absent in …

[HTML][HTML] Follicular T helper cells shape the HCV-specific CD4+ T cell repertoire after virus elimination

M Smits, K Zoldan, N Ishaque, Z Gu… - The Journal of …, 2020 - Am Soc Clin Investig
BACKGROUND Chronic hepatitis C virus (HCV) infection is characterized by a severe
impairment of HCV-specific CD4+ T cell help that is driven by chronic antigen stimulation …

Suppression of HCV-specific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infection

K Sugimoto, F Ikeda, J Stadanlick, FA Nunes, HJ Alter… - Hepatology, 2003 - Elsevier
Hepatitis C virus (HCV) has a high propensity for persistence. To better define the
immunologic determinants of HCV clearance and persistence, we examined the circulating …

[HTML][HTML] Chronic HCV infection promotes cytotoxicity in antigen-specific CD8+ T cells regardless of virus specificity

AC Maretti-Mira, MP Salomon, AM Hsu… - Frontiers in …, 2023 - frontiersin.org
Introduction: Despite advancements in hepatitis C virus (HCV) infection treatment, HCV still
represents a significant public health burden. Besides progressive hepatic damage, viral …

Virological footprint of CD4+ T-cell responses during chronic hepatitis C virus infection

VM Fleming, G Harcourt, E Barnes… - Journal of General …, 2010 - microbiologyresearch.org
Human and animal model evidence suggests that CD4+ T cells play a critical role in the
control of chronic hepatitis C virus (HCV) infection. However, despite their importance, the …