Although recognized as a curable disease, the persistence of hepatitis C virus (HCV) in
chronically infected patients remains a great burden for public health. T cell immune …

Background and Aims Hepatitis C virus (HCV) leads to a high rate of chronic infection and T
cell dysfunction. Although it is well known that chronic antigenic stimulation is a driving force …

CD4+ T cell failure is a hallmark of chronic hepatitis C virus (HCV) infection. However, the
mechanisms underlying the impairment and loss of virus-specific CD4+ T cells in persisting …

Chronic hepatitis C virus (HCV) infection is characterized by attenuated antiviral T‐cell
responses, making their detection and characterization a technological challenge. The role …

Hepatitis C virus (HCV)-specific T cell responses are closely linked to the clinical course of
infection. While T cell responses in self-limiting infection are typically broad and multi …

Vigorous proliferative CD4+ T cell responses are the hallmark of spontaneous clearance of
acute hepatitis C virus (HCV) infection, whereas comparable responses are absent in …

BACKGROUND Chronic hepatitis C virus (HCV) infection is characterized by a severe
impairment of HCV-specific CD4+ T cell help that is driven by chronic antigen stimulation …

Hepatitis C virus (HCV) has a high propensity for persistence. To better define the
immunologic determinants of HCV clearance and persistence, we examined the circulating …

Introduction: Despite advancements in hepatitis C virus (HCV) infection treatment, HCV still
represents a significant public health burden. Besides progressive hepatic damage, viral …

Human and animal model evidence suggests that CD4+ T cells play a critical role in the
control of chronic hepatitis C virus (HCV) infection. However, despite their importance, the …