Aims The nephrotoxicity of cyclosporine A (CsA) limits its use as an immunosuppressant.
Wnt/β-catenin signaling is involved in the pathogenesis of both acute and chronic kidney …

Gentamicin-induced nephrotoxicity has been well documented, although the causing
mechanisms and preventative measures need further investigation. The current study aimed …

Gentamicin is a commonly used aminoglycoside antibiotic. However, its therapeutic use is
limited by its nephrotoxicity. The mechanisms of gentamicin-induced nephrotoxicity are …

Cyclosporine A (CsA) is employed for organ transplantation and autoimmune disorders.
Nephrotoxicity is a serious side effect that hampers the therapeutic use of CsA. Hesperidin …

Inflammation and oxidative stress play important roles in the progression of renal damage.
The natural polyphenol naringenin is known to exert potent antioxidant and anti …

The present study aimed to investigate the role of α and β-adrenergic receptors (βARs) in
mediation or modulation of the dexamethasone-induced nephrotoxicity by using different …

Despite that cyclosporine-A (CsA) is a widely used immunosuppressive drug, its nephrotoxic
effect limits its long-term administration. Herein we tried to investigate its renal effect on …

Cyclosporine A (CsA) is a potent and effective immunosuppressive agent, but its use is
frequently accompanied by severe renal toxicity. The causes for the nephrotoxicity of CsA …

Aims Cyclophosphamide is an alkylating agent with vast arrays of therapeutic activity.
Currently, its medical use is limited due to its numerous adverse events, including …

Purpose We recently reported that rosiglitazone (RGTZ), a peroxisome proliferator-activated
receptor gamma (PPARγ) agonist, has a protective effect against cyclosporine (CsA) …