The neuroimmunomodulation hypothesis for Alzheimer's disease (AD) postulates that
alterations in the innate immune system triggered by damage signals result in adverse …

In the present work, we briefly review the evidence on the key role played by the
neuroimmunoendocrine network in the etiopathogenesis of Alzheimer's disease (AD) and …

The crosstalk in the functional interplay of the neuroimmune system is essential to ensure
homeostasis preservation and health. Alzheimer's disease (AD) can be understood in the …

Background The risk of developing Alzheimer's disease (AD) is modulated by genetic and
environmental factors. Early-life stress (ELS) exposure during critical periods of brain …

Prenatal stress (PS) has long-term sequelae for the morphological and functional status of
the central nervous system of the progeny. A PS-induced proinflammatory status of the …

A hallmark of the aged immune system is impaired immunoregulation of the innate and
adaptive immune system in the periphery and also in the central nervous system (CNS) …

This article is part of a Special Issue “Neuroendocrine-Immune Axis in Health and Disease.”
Healthy aged individuals are more likely to suffer profound memory impairments following a …

The 3xTg‐AD mouse develops a progressive Alzheimer′ s disease‐(AD‐) like brain
pathology that causes cognitive‐and neuropsychiatric‐like symptoms of dementia. Since its …

Mid-adulthood represents the critical window period usually associated with the
development of age-related diseases. Despite several attempts to delineate the pathological …

Neurodegenerative diseases such as Alzheimer's disease (AD) can be understood in the
context of the aging of neuroimmune communication. Although the contribution to AD of the …