All biological tissues and bodily fluids include the autacoid adenosine. The P1 class of
purinergic receptors includes adenosine receptors. Four distinct G-protein-coupled …

The A2A adenosine receptor is a protein belonging to a family of four GPCR adenosine
receptors. It is involved in the regulation of several pathophysiological conditions in both the …

Adenosine A2B and, much more importantly, adenosine A2A receptors modulate many
physiological and pathological processes in the brain. In this review, the most recent …

According to DSM5, the term neurocognitive disorder (NCD) emphasizes that the cause of
mental deficit lies in a pathology affecting neuronal circuits. The early clinical stages of NCD …

Background: Alzheimer's disease (AD) is the most common form of dementia worldwide,
with approximately 6 million cases reported in America in 2020. The clinical signs of AD …

Although significant progress has been made in the past few decades demonstrating that
adenosine modulates a variety of physiological and pathophysiological processes through …

Adenosine signals through four distinct G protein-coupled receptors that are located at
various synapses, cell types and brain areas. Through them, adenosine regulates …

The inhibitory adenosine A1 receptor (A1R) and excitatory A2A receptor (A2AR) are
predominantly expressed in the brain. Whereas the A2AR has been implicated in normal …

Endogenous nucleoside adenosine modulates a number of physiological effects through
interaction with P1 purinergic receptors. All of them are G protein-coupled receptors, and, to …

Adenosine A2A receptors are members of the G protein-coupled receptor family and
mediate multiple physiological effects of adenosine, both at the central nervous system …