Background Genetic variation and epigenetic mechanisms involving the stress-related gene
FKBP5 have been implicated in the intergenerational transmission of trauma-related effects …

Objective: There is growing evidence that exposure to trauma prior to conception can affect
offspring. The authors have reported that adult offspring of Holocaust survivors showed …

Background Survivors of child abuse experience high rates of adverse physical and mental
health outcomes. Epigenetic alterations in the stress response system, the FKBP5 gene …

Background The involvement of epigenetic mechanisms in intergenerational transmission of
stress effects has been demonstrated in animals but not in humans. Methods Cytosine …

Adverse maternal environments can lead to increased fetal exposure to maternal cortisol,
which can cause infant neurobehavioral deficits. The placenta regulates fetal cortisol …

FKBP5 is thought to be involved in the pathogenesis of stress-related disorders. Studies
have shown that FKBP5 genotypes moderate the risk of post-traumatic stress disorder and …

Background The inconsistency in results of cortisol alterations after childhood maltreatment
(CM) might arise due to the fact that no study so far considered the effects of environmental …

Childhood trauma is a well-established risk factor for mental and physical health problems
over the life course (Anda et al, 2005). However, individuals vary widely in response to …

Context In addition to trauma exposure, other factors contribute to risk for development of
posttraumatic stress disorder (PTSD) in adulthood. Both genetic and environmental factors …

Background Childhood trauma has been associated with a heightened risk for presenting
clinical and non-clinical psychopathology in adulthood. Genes related with the stress …