Background Lyme borreliosis, potentially associated with serious long-term complications, is
caused by the species complex Borrelia burgdorferi sensu lato. We investigated a novel …

Background Lyme borreliosis is caused by Borrelia burgdorferi sensu stricto in the USA and
by several Borrelia species in Europe and Asia, but no human vaccine is available. We …

Lyme borreliosis (LB) patients who recover, as well as previously infected asymptomatic
individuals, remain vulnerable to reinfection with Borrelia burgdorferi sensu lato. There is …

We have previously shown that the Outer surface protein A (OspA) based Lyme borreliosis
vaccine VLA15 induces protective immunity in mice. Herein, we report the induction of …

There is currently no Lyme borreliosis vaccine available for humans, although it has been
shown that the disease can be prevented by immunization with an OspA-based vaccine …

The development of vaccines for prevention of diseases caused by pathogenic species can
encounter major obstacles if high sequence diversity is observed between individual strains …

Background Lyme disease is a multisystem inflammatory disease caused by infection with
the tick-borne spirochete Borrelia burgdorferi and is the most common vector-borne infection …

Lyme borreliosis is a multi-organ infection caused by spirochetes of the Borrelia burgdorferi
sensu lato group with its species B burgdorferi sensu stricto, Borrelia garinii, and Borrelia …

The expansion of Lyme borreliosis endemic areas and the corresponding increase of
disease incidence have opened the possibility for greater acceptance of a vaccine. In this …

Lyme disease is caused by the spirochete Borrelia burgdorferi and it is the most common
vector-borne disease in the United States. Disseminated spirochetes can persist in various …