PCB126-mediated effects on adipocyte energy metabolism and adipokine secretion may result in abnormal glucose uptake in muscle cells

A Caron, F Ahmed, V Peshdary, L Garneau, E Atlas… - bioRxiv, 2020 - biorxiv.org
Background Exposure to coplanar polychlorinated biphenyls (PCBs) is linked to the
development of insulin resistance. Previous studies suggested that PCB126 alters muscle …

Effects of PCB126 on Adipose-to-Muscle Communication in an in Vitro Model

A Caron, F Ahmed, V Peshdary… - Environmental …, 2020 - ehp.niehs.nih.gov
Background: Exposure to coplanar polychlorinated biphenyls (PCBs) is linked to the
development of insulin resistance. Previous studies suggested PCB126 alters muscle …

Polychlorinated biphenyl 126 exposure in L6 myotubes alters glucose metabolism: a pilot study

JF Mauger, L Nadeau, A Caron, NA Chapados… - … Science and Pollution …, 2016 - Springer
Polychlorinated biphenyls (PCBs) are increasingly recognized as metabolic disruptors. Due
to its mass, skeletal muscle is the major site of glucose disposal. While muscle mitochondrial …

[HTML][HTML] CYP1A1, VEGFA and adipokine responses of human adipocytes co-exposed to PCB126 and hypoxia

ZE Amine, JF Mauger, P Imbeault - Cells, 2022 - mdpi.com
It is increasingly recognized that hypoxia may develop in adipose tissue as its mass
expands. Adipose tissue is also the main reservoir of lipophilic pollutants, including …

Polychlorinated biphenyls exposure-induced insulin resistance is mediated by lipid droplet enlargement through Fsp27

HY Kim, WY Kwon, YA Kim, YJ Oh, SH Yoo… - Archives of …, 2017 - Springer
Although epidemiological and experimental studies demonstrated that polychlorinated
biphenyls (PCBs) lead to insulin resistance, the mechanism underlying PCBs-induced …

[HTML][HTML] The transcriptional effects of PCB118 and PCB153 on the liver, adipose tissue, muscle and colon of mice: highlighting of Glut4 and Lipin1 as main target …

A Mesnier, S Champion, L Louis, C Sauzet, P May… - PLoS …, 2015 - journals.plos.org
Epidemiological studies have associated environmental exposure to polychlorinated
biphenyls (PCBs) with an increased risk of type 2 diabetes; however, little is known about …

Polychlorinated biphenyl 126 exposure in rats alters skeletal muscle mitochondrial function

C Tremblay-Laganière, L Garneau, JF Mauger… - … Science and Pollution …, 2019 - Springer
In the past few years, polychlorinated biphenyls (PCBs), a class of environmental pollutants,
have been associated with metabolism dysregulation. Muscle is one of the key regulators of …

PCB126 inhibits adipogenesis of human preadipocytes

G Gadupudi, FA Gourronc, G Ludewig, LW Robertson… - Toxicology in Vitro, 2015 - Elsevier
Emerging evidence indicates that persistent organic pollutants (POPs), including
polychlorinated biphenyls (PCBs), are involved in the development of diabetes …

Polychlorinated biphenyl 138 exposure-mediated lipid droplet enlargement endows adipocytes with resistance to TNF-α-induced cell death

YA Kim, HY Kim, YJ Oh, WY Kwon, MH Lee, JY Bae… - Toxicology Letters, 2018 - Elsevier
Although epidemiological reports have shown the association between polychlorinated
biphenyls (PCBs) and obesity, the molecular mechanism of PCB-induced obesity is mostly …

[HTML][HTML] Increased FAT/CD36 cycling and lipid accumulation in myotubes derived from obese type 2 diabetic patients

C Aguer, M Foretz, L Lantier, S Hebrard, B Viollet… - PLoS …, 2011 - journals.plos.org
Background Permanent fatty acid translocase (FAT/) CD36 relocation has previously been
shown to be related to abnormal lipid accumulation in the skeletal muscle of type 2 diabetic …