BACKGROUND & AIMS: Brain imaging studies have identified abnormal rectal-evoked
responses and cortical thinning in patients with irritable bowel syndrome (IBS). However, it is …

AIM To evaluate brain involvement in quiescent Crohn's disease (CD) patients with fatigue
using quantitative magnetic resonance imaging (MRI). METHODS Multiple MRI techniques …

While a variety of peripheral candidate biomarkers related to functional gastrointestinal
disorders (FGIDs) continue to be investigated, none appear to account for a large proportion …

Background Neurological involvement and psychiatric manifestations have been
documented in clinical cases of inflammatory bowel disease (IBD); however, the presence of …

Following up on the previous Research Topic entitled “Neurogastroenterology–Focus on the
gut-brain axis” published in 2021 (1) an update was planned this year reflecting the …

Methods The voxel-wise analysis of the diffusion parameters was used to quantify the white
matter changes of female brains in 18 FC patients and 20 IBS-C patients compared with a …

Background Inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and
Crohn's disease (CD), is a chronic, progressive, and recurrent intestinal condition that poses …

Alterations in brain–gut–microbiome (BGM) interactions have been implicated in the
pathogenesis of irritable bowel syndrome (IBS). Here, we apply a systems biology approach …

The gut and brain are increasingly linked in human disease, with neuropsychiatric
conditions classically attributed to the brain showing an involvement of the intestine and …

Objective: It is common that major depressive disorder (MDD) is accompanied by
gastrointestinal (GI) symptoms. However, few studies have focused on the clinical …