Biology of the radio-and chemo-responsiveness in HPV malignancies

MT Spiotto, CM Taniguchi, AH Klopp, LE Colbert… - Seminars in radiation …, 2021 - Elsevier
In multiple anatomic sites, patients with cancers associated with the Human Papillomavirus
(HPV) experience better locoregional control and overall survival after radiotherapy and/or …

The Causes and Consequences of DNA Damage and Chromosomal Instability Induced by Human Papillomavirus

KM Jones, A Bryan, E McCunn, PE Lantz, H Blalock… - Cancers, 2024 - mdpi.com
Simple Summary Human papillomavirus (HPV) causes 5% of cancers and is the main cause
of oropharyngeal cancer in the United States and of cervical cancer worldwide. HPV …

Unravelling the biology of human papillomavirus (HPV) related tumours to enhance their radiosensitivity

MC Vozenin, HK Lord, D Hartl, E Deutsch - Cancer treatment reviews, 2010 - Elsevier
HPV infection is associated with most squamous cell carcinomas (SCC) of the uterine cervix
and many head and neck SCC. While recent understanding of the mechanisms of HPV …

Modulation of radiation sensitivity and antitumor immunity by viral pathogenic factors: Implications for radio-immunotherapy

F Rödel, D Martin, P Balermpas, U Wieland… - … et Biophysica Acta (BBA …, 2019 - Elsevier
Several DNA viruses including Human Papillomavirus (HPV), Epstein-Barr virus (EBV), and
Human cytomegalovirus (HCMV) are mechanistically associated with the development of …

[HTML][HTML] Molecular mechanisms underlying increased radiosensitivity in human papillomavirus-associated oropharyngeal squamous cell carcinoma

H Wang, B Wang, J Wei, L Meng, Q Zhang… - … Journal of Biological …, 2020 - ncbi.nlm.nih.gov
Oropharyngeal squamous cell carcinoma (OPSCC) is an important type of head and neck
squamous cell carcinoma (HNSCC). The traditional risk factors for OPSCC include …

Enhanced radiation sensitivity in HPV-positive head and neck cancer

RJ Kimple, MA Smith, GC Blitzer, AD Torres, JA Martin… - Cancer research, 2013 - AACR
Patients with human papillomavirus (HPV+)–associated head and neck cancer (HNC) show
significantly improved survival outcome compared with those with HPV-negative (HPV−) …

Increased radiosensitivity of HPV-positive head and neck cancers: Molecular basis and therapeutic perspectives

H Mirghani, F Amen, Y Tao, E Deutsch, A Levy - Cancer treatment reviews, 2015 - Elsevier
Human papillomavirus driven head and neck squamous cell carcinoma (HNSCC),
particularly oropharyngeal squamous cell carcinoma (OPSCC), are characterized by a …

The radiobiology of HPV-positive and HPV-negative head and neck squamous cell carcinoma

C Zhou, JL Parsons - Expert reviews in molecular medicine, 2020 - cambridge.org
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer
worldwide, with reported incidences of~ 800 000 cases each year. One of the critical …

Modulation of therapeutic sensitivity by human papillomavirus

AD Swick, A Chatterjee, AMA De Costa… - Radiotherapy and …, 2015 - Elsevier
Human papillomaviruses (HPVs) are small double-stranded DNA viruses that pose
significant public health concerns as the causative agent of approximately 5% of worldwide …

Targeting DNA double-strand break repair enhances radiosensitivity of HPV-positive and HPV-negative head and neck squamous cell carcinoma to photons and …

ET Vitti, A Kacperek, JL Parsons - Cancers, 2020 - mdpi.com
The response of head and neck squamous cell carcinoma (HNSCC) to radiotherapy
depends on human papillomavirus type 16 (HPV) status, and where improved outcome and …