Background The receptor encoded by the MET oncogene and its ligand Hepatocyte Growth
Factor (HGF) are at the core of the invasive-metastatic behavior. In a number of instances …

Purpose: MET, the receptor for hepatocyte growth factor (HGF), has been implicated in
driving tumor proliferation and metastasis. High MET expression is correlated with poor …

The receptor for hepatocyte growth factor (HGF), a tyrosine kinase encoded by the Met
oncogene, has a crucial role in cancer growth, invasion and metastasis. It is a validated …

MET, a master gene sustaining “invasive growth,” is a relevant target for cancer precision
therapy. In the vast majority of tumors, wild‐type MET behaves as a “stress‐response” gene …

Met, the high affinity receptor for hepatocyte growth factor, is one of the most frequently
activated tyrosine kinases in human cancer and a validated target for cancer therapy. We …

An awesome number of experimental and clinical evidences indicate that constitutive
activation of the Met oncogenic receptor plays a critical role in the progression of cancer …

Background c-Met is the receptor tyrosine kinase for hepatocyte growth factor (HGF)
encoded by the MET proto-oncogene. Aberrant activation of c-Met resulting from MET …

The receptor tyrosine kinase MET is a major component controlling the invasive growth
program in embryonic development and in invasive malignancies. The discovery of …

Activation of the Met receptor tyrosine kinase, either by its ligand, hepatocyte growth factor
(HGF), or via ligand-independent mechanisms, such as MET amplification or receptor …

Hepatocyte growth factor (HGF) and its receptor MET represent validated targets for cancer
therapy. However, HGF/MET inhibitors being explored as cancer therapeutics exhibit …