Nucleotide-binding leucine-rich repeat-containing proteins, or NOD-like receptors (NLRs),
are intracellular innate immune sensors that can regulate several signaling pathways …

NLRs play fundamental roles in host-defense and inflammatory disorders. NLRP6 is a newly
characterized member of this family that inhibits NF-κB and MAP-kinase dependent immune …

Appropriate immune responses require a fine balance between immune activation and
attenuation. NLRC3, a non-inflammasome-forming member of the NLR innate immune …

Nod-like receptors (NLRs) are intracellular sensors that respond to a variety of pathogen
and intracellular danger signals to induce innate immune responses. NLRC5 has recently …

Mammalian nucleotide-binding domain leucine-rich repeat containing proteins (NLRs) are
important pattern-recognition receptors, still the function of many NLRs remains poorly …

Recent data have shown that nucleotide-binding domain leucine-rich repeat proteins
(NLRs), a class of innate immune receptors that respond to pathogen attack or cellular …

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease and the
pathogenesis remains unclear. Previous studies suggested that fibroblast-like synoviocytes …

Cell death is an essential immunological apparatus of host defense, but dysregulation of
mutually inclusive cell deaths poses severe threats during microbial and parasitic infections …

NLRC5 is an important regulator in innate immune responses. However, the ability of
NLRC5 to inhibit NF-κB activation is controversial in different cell types. How dynamic …

The NLRP3 inflammasome represents a cytoplasmic multiprotein complex with the
capability to recognize a wide range of pathogen-derived, environmental, and endogenous …