Bladder cancer is the 10th most diagnosed cancer, with almost 10 M cancer deaths last year
worldwide. Currently, chemotherapy is widely used as adjuvant therapy after surgical …

Survivin is known to be overexpressed in numerous tumor types including human bladder
cancer and to cause resistance to radiation and chemotherapy. Therefore, we tested the …

Purpose: Survivin inhibits apoptosis and enables tumor cells to escape from therapy
induced senescence. High survivin expression is associated with bladder cancer …

Penetration of the bladder permeability barrier (BPB) is a major challenge when treating
bladder diseases via intravesical delivery. To increase transurothelial migration and tissue …

Survivin is recognized as a general target in cancer therapy because of its selective
overexpression in the majority of tumors. In bladder cancer (BCa), its expression correlates …

In order to reduce side effects of survivin-inhibiting anticancer therapies, we determined the
expression of the survivin transcripts survivin-wild-type (survivin-wt), survivin-ΔEx3 (ΔEx3) …

OBJECTIVE To investigate the effects of survivin gene RNA interference on cell growth and
the cell cycle in the human bladder cancer cell line T24. MATERIALS AND METHODS A …

Survivin stands out as one of the most specific cancer targets discovered to date. Although
single inhibition, eg through small interfering RNA (siRNA), has shown modest results in …

Background Bladder cancer is the most common type of urinary system tumours. It is
frequently associated with genetic mutations that deregulate the cell cycle and render these …

Ovarian cancer is a dreadful disease estimated to be the second most common gynecologic
malignancy worldwide. Its current therapy, based on cytoreductive surgery followed by the …