Role of the type 2 iodothyronine deiodinase (D2) in the control of thyroid hormone signaling
RA e Drigo, TL Fonseca… - … et Biophysica Acta (BBA …, 2013 - Elsevier
BACKGROUND: Thyroid hormone signaling is critical for development, growth and
metabolic control in vertebrates. Although serum concentration of thyroid hormone is …
metabolic control in vertebrates. Although serum concentration of thyroid hormone is …
Type 2 deiodinase at the crossroads of thyroid hormone action
RA e Drigo, AC Bianco - The international journal of biochemistry & cell …, 2011 - Elsevier
Thyroid hormone action can be customized on a cell-specific fashion through the controlled
action of the deiodinase group of enzymes, which are homodimeric thioredoxin fold …
action of the deiodinase group of enzymes, which are homodimeric thioredoxin fold …
The deiodinase trio and thyroid hormone signaling
AC Bianco, RR da Conceição - Thyroid Hormone Nuclear Receptor …, 2018 - Springer
Thyroid hormone signaling is customized in a time and cell-specific manner by the
deiodinases, homodimeric thioredoxin fold containing selenoproteins. This ensures …
deiodinases, homodimeric thioredoxin fold containing selenoproteins. This ensures …
Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling
B Gereben, AM Zavacki, S Ribich, BW Kim… - Endocrine …, 2008 - academic.oup.com
The iodothyronine deiodinases initiate or terminate thyroid hormone action and therefore
are critical for the biological effects mediated by thyroid hormone. Over the years, research …
are critical for the biological effects mediated by thyroid hormone. Over the years, research …
Activation and inactivation of thyroid hormone by deiodinases: local action with general consequences
B Gereben, A Zeöld, M Dentice, D Salvatore… - Cellular and Molecular …, 2008 - Springer
The thyroid hormone plays a fundamental role in the development, growth, and metabolic
homeostasis in all vertebrates by affecting the expression of different sets of genes. A group …
homeostasis in all vertebrates by affecting the expression of different sets of genes. A group …
[PDF][PDF] THEMATIC REVIEW Deiodinases: the balance of thyroid hormone Local control of thyroid hormone action: role of type 2 deiodinase
GR Williams, JHD Bassett - Journal of Endocrinology, 2011 - Citeseer
The thyroid gland predominantly secretes the pro-hormone thyroxine (T4) that is converted
to the active hormone 3, 5, 30-L-triiodothyronine (T3) in target cells. Conversion of T4 to T3 …
to the active hormone 3, 5, 30-L-triiodothyronine (T3) in target cells. Conversion of T4 to T3 …
Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases
The goal of this review is to place the exciting advances that have occurred in our
understanding of the molecular biology of the types 1, 2, and 3 (D1, D2, and D3 …
understanding of the molecular biology of the types 1, 2, and 3 (D1, D2, and D3 …
Regulation of type 1 iodothyronine deiodinase in health and disease
RJ Koenig - Thyroid, 2005 - liebertpub.com
The major physiologic function of type 1 iodothyronine deiodinase (D1) is to produce
triiodothyronine (T3) for the plasma. D1 activity is regulated by numerous factors, perhaps …
triiodothyronine (T3) for the plasma. D1 activity is regulated by numerous factors, perhaps …
Deiodinases and the metabolic code for thyroid hormone action
SC Russo, F Salas-Lucia, AC Bianco - Endocrinology, 2021 - academic.oup.com
Deiodinases modify the biological activity of thyroid hormone (TH) molecules, ie, they may
activate thyroxine (T4) to 3, 5, 3′-triiodothyronine (T3), or they may inactivate T3 to 3, 3 …
activate thyroxine (T4) to 3, 5, 3′-triiodothyronine (T3), or they may inactivate T3 to 3, 3 …
[HTML][HTML] Deiodinases and the three types of thyroid hormone deiodination reactions
L Sabatino, C Vassalle… - Endocrinology and …, 2021 - synapse.koreamed.org
Thyroid hormone (TH) signaling is strictly regulated by iodothyronine deiodinase activity,
which both preserves the circulating levels of the biologically active triiodothyronine (T3) and …
which both preserves the circulating levels of the biologically active triiodothyronine (T3) and …