Fibroblast activation protein–specific PET/CT imaging in fibrotic interstitial lung diseases and lung cancer: a translational exploratory study

M Röhrich, D Leitz, FM Glatting, AK Wefers… - Journal of nuclear …, 2022 - Soc Nuclear Med
Interstitial lung diseases (ILDs) comprise over 200 parenchymal lung disorders. Among
them, fibrosing ILDs, especially idiopathic pulmonary fibrosis, are associated with a poor …

[68 Ga]Ga-FAPI-46 PET for non-invasive detection of pulmonary fibrosis disease activity

ZT Rosenkrans, CF Massey, K Bernau… - European journal of …, 2022 - Springer
Purpose The lack of effective molecular biomarkers to monitor idiopathic pulmonary fibrosis
(IPF) activity or treatment response remains an unmet clinical need. Herein, we determined …

Comprehensive analysis of fibroblast activation protein expression in interstitial lung diseases

P Yang, Q Luo, X Wang, Q Fang, Z Fu, J Li… - American Journal of …, 2023 - atsjournals.org
Rationale: Sustained activation of lung fibroblasts and the resulting oversynthesis of the
extracellular matrix are detrimental events for patients with interstitial lung diseases (ILDs) …

Areas of normal pulmonary parenchyma on HRCT exhibit increased FDG PET signal in IPF patients

T Win, BA Thomas, T Lambrou, BF Hutton… - European journal of …, 2014 - Springer
Purpose Patients with idiopathic pulmonary fibrosis (IPF) show increased PET signal at sites
of morphological abnormality on high-resolution computed tomography (HRCT). The …

Pulmonary 18F-FDG uptake helps refine current risk stratification in idiopathic pulmonary fibrosis (IPF)

T Win, NJ Screaton, JC Porter, B Ganeshan… - European journal of …, 2018 - Springer
Purpose There is a lack of prognostic biomarkers in idiopathic pulmonary fibrosis (IPF)
patients. The objective of this study is to investigate the potential of 18 F-FDG-PET/CT to …

Experimental and quantitative imaging techniques in interstitial lung disease

ND Weatherley, JA Eaden, NJ Stewart, BJ Bartholmai… - Thorax, 2019 - thorax.bmj.com
Interstitial lung diseases (ILDs) are a heterogeneous group of conditions, with a wide and
complex variety of imaging features. Difficulty in monitoring, treating and exploring novel …

FAPI compared with FDG PET/CT for diagnosis of primary and metastatic lung cancer

Y Wei, L Ma, P Li, J Lu, J Ren, S Yan, H Wu, S Yuan… - Radiology, 2023 - pubs.rsna.org
Background The radiotracer fluorine 18 (18F)–labeled fibroblast activation protein inhibitor
(FAPI) has shown promise for visualizing several types of cancer, but the accuracy of 18F …

Idiopathic pulmonary fibrosis and diffuse parenchymal lung disease: implications from initial experience with 18F-FDG PET/CT

AM Groves, T Win, NJ Screaton, M Berovic… - Journal of Nuclear …, 2009 - Soc Nuclear Med
The purpose of this study was to evaluate integrated 18F-FDG PET/CT in patients with
idiopathic pulmonary fibrosis (IPF) and diffuse parenchymal lung disease (DPLD). Methods …

Type I collagen–targeted PET probe for pulmonary fibrosis detection and staging in preclinical models

P Désogère, LF Tapias, LP Hariri, NJ Rotile… - Science translational …, 2017 - science.org
Pulmonary fibrosis is scarring of the lungs that can arise from radiation injury, drug toxicity,
environmental or genetic causes, and for unknown reasons [idiopathic pulmonary fibrosis …

[18F]FDG PET/CT predicts progression-free survival in patients with idiopathic pulmonary fibrosis

A Justet, A Laurent-Bellue, G Thabut, A Dieudonné… - Respiratory …, 2017 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by an
unpredictable course. Prognostic markers and disease activity markers are needed. The …