Fibroblast activation protein–specific PET/CT imaging in fibrotic interstitial lung diseases and lung cancer: a translational exploratory study
M Röhrich, D Leitz, FM Glatting, AK Wefers… - Journal of nuclear …, 2022 - Soc Nuclear Med
Interstitial lung diseases (ILDs) comprise over 200 parenchymal lung disorders. Among
them, fibrosing ILDs, especially idiopathic pulmonary fibrosis, are associated with a poor …
them, fibrosing ILDs, especially idiopathic pulmonary fibrosis, are associated with a poor …
[68 Ga]Ga-FAPI-46 PET for non-invasive detection of pulmonary fibrosis disease activity
ZT Rosenkrans, CF Massey, K Bernau… - European journal of …, 2022 - Springer
Purpose The lack of effective molecular biomarkers to monitor idiopathic pulmonary fibrosis
(IPF) activity or treatment response remains an unmet clinical need. Herein, we determined …
(IPF) activity or treatment response remains an unmet clinical need. Herein, we determined …
Comprehensive analysis of fibroblast activation protein expression in interstitial lung diseases
P Yang, Q Luo, X Wang, Q Fang, Z Fu, J Li… - American Journal of …, 2023 - atsjournals.org
Rationale: Sustained activation of lung fibroblasts and the resulting oversynthesis of the
extracellular matrix are detrimental events for patients with interstitial lung diseases (ILDs) …
extracellular matrix are detrimental events for patients with interstitial lung diseases (ILDs) …
Areas of normal pulmonary parenchyma on HRCT exhibit increased FDG PET signal in IPF patients
Purpose Patients with idiopathic pulmonary fibrosis (IPF) show increased PET signal at sites
of morphological abnormality on high-resolution computed tomography (HRCT). The …
of morphological abnormality on high-resolution computed tomography (HRCT). The …
Pulmonary 18F-FDG uptake helps refine current risk stratification in idiopathic pulmonary fibrosis (IPF)
Purpose There is a lack of prognostic biomarkers in idiopathic pulmonary fibrosis (IPF)
patients. The objective of this study is to investigate the potential of 18 F-FDG-PET/CT to …
patients. The objective of this study is to investigate the potential of 18 F-FDG-PET/CT to …
Experimental and quantitative imaging techniques in interstitial lung disease
ND Weatherley, JA Eaden, NJ Stewart, BJ Bartholmai… - Thorax, 2019 - thorax.bmj.com
Interstitial lung diseases (ILDs) are a heterogeneous group of conditions, with a wide and
complex variety of imaging features. Difficulty in monitoring, treating and exploring novel …
complex variety of imaging features. Difficulty in monitoring, treating and exploring novel …
FAPI compared with FDG PET/CT for diagnosis of primary and metastatic lung cancer
Y Wei, L Ma, P Li, J Lu, J Ren, S Yan, H Wu, S Yuan… - Radiology, 2023 - pubs.rsna.org
Background The radiotracer fluorine 18 (18F)–labeled fibroblast activation protein inhibitor
(FAPI) has shown promise for visualizing several types of cancer, but the accuracy of 18F …
(FAPI) has shown promise for visualizing several types of cancer, but the accuracy of 18F …
Idiopathic pulmonary fibrosis and diffuse parenchymal lung disease: implications from initial experience with 18F-FDG PET/CT
The purpose of this study was to evaluate integrated 18F-FDG PET/CT in patients with
idiopathic pulmonary fibrosis (IPF) and diffuse parenchymal lung disease (DPLD). Methods …
idiopathic pulmonary fibrosis (IPF) and diffuse parenchymal lung disease (DPLD). Methods …
Type I collagen–targeted PET probe for pulmonary fibrosis detection and staging in preclinical models
P Désogère, LF Tapias, LP Hariri, NJ Rotile… - Science translational …, 2017 - science.org
Pulmonary fibrosis is scarring of the lungs that can arise from radiation injury, drug toxicity,
environmental or genetic causes, and for unknown reasons [idiopathic pulmonary fibrosis …
environmental or genetic causes, and for unknown reasons [idiopathic pulmonary fibrosis …
[18F]FDG PET/CT predicts progression-free survival in patients with idiopathic pulmonary fibrosis
Background Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by an
unpredictable course. Prognostic markers and disease activity markers are needed. The …
unpredictable course. Prognostic markers and disease activity markers are needed. The …
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