Abstract Background The incidence of Papillary thyroid carcinoma (PTC), the most common
type of thyroid malignancy, has risen rapidly worldwide. PTC usually has an excellent …

The contribution of intratumor heterogeneity to thyroid metastatic cancers is still unknown.
The clonal relationships between the primary thyroid tumors and lymph nodes (LN) or …

The tumor ecosystem of papillary thyroid carcinoma (PTC) is poorly characterized. Using
single-cell RNA sequencing, we profile transcriptomes of 158,577 cells from 11 patients' …

The immune system plays critical roles in tumor prevention, but also in its initiation and
progression. Tumors are subjected to immunosurveillance, but cancer cells generate an …

BACKGROUND. Poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer
(ATC) are rare and frequently lethal tumors that so far have not been subjected to …

The incidence of thyroid cancers has been steadily increasing worldwide over the past few
decades. Although five-year survival rates for differentiated thyroid cancers are upwards of …

Background The relationship between Hashimoto thyroiditis (HT) and papillary thyroid
carcinoma (PTC) remains uncertain. We assessed the impact of HT on the tumor immune …

We report the successful validation of a combined gene expression profiling and tissue
microarray approach to papillary thyroid carcinoma (PTC) biomarker identification. Our …

Objective Immune responses against differentiated thyroid carcinomas (DTC) have long
been recognized. We aimed to investigate the role of immune cell infiltration in the …

Background Thyroid cancer and thyroid autoimmunity are considered opposite extremes of
immune-responses. However, several studies have suggested that thyroid cancer coexists …