Metabolic changes in female rats exposed to intrauterine hyperglycemia and postweaning consumption of high-fat diet

VG Paula, YK Sinzato… - Biology of …, 2022 - academic.oup.com
We evaluated the influence of the hyperglycemic intrauterine environment and postweaning
consumption of a high-fat diet (HFD) on the glycemia, insulin, lipid, and immunological …

Maternal high‐fat diet promotes onset of diabetes in rat offspring

T Ohta, Y Toriniwa, N Ryumon, N Inaba… - Animal Science …, 2017 - Wiley Online Library
The onset and progression of type II diabetes is closely related to environmental factors, in
particular dietary habit. Moreover, the environmental exposures very early in life can …

[HTML][HTML] Fetal hyperglycemia and a high-fat diet contribute to aberrant glucose tolerance and hematopoiesis in adult rats

EK Blue, K Ballman, F Boyle, E Oh, T Kono… - Pediatric …, 2015 - nature.com
Background: Children exposed to gestational diabetes mellitus (GDM) during pregnancy are
at increased risk of obesity, diabetes, and hypertension. Our goal was to identify metabolic …

Maternal high-fat diet induces insulin resistance and deterioration of pancreatic β-cell function in adult offspring with sex differences in mice

H Yokomizo, T Inoguchi, N Sonoda… - American Journal …, 2014 - journals.physiology.org
Intrauterine environment may influence the health of postnatal offspring. There have been
many studies on the effects of maternal high-fat diet (HFD) on diabetes and glucose …

[HTML][HTML] Congenital anomalies programmed by maternal diabetes and obesity on offspring of rats

VC Araujo-Silva, A Santos-Silva, AS Lourenço… - Frontiers in …, 2021 - frontiersin.org
Embryo-fetal exposure to maternal disorders during intrauterine life programs long-term
consequences for the health and illness of offspring. In this study, we evaluated whether …

Effect of a high-fat diet on diabetic mother rats and their offspring through three generations

R Nasu, K Seki, M Nara, M Murakami, T Kohama - Endocrine journal, 2007 - jstage.jst.go.jp
Pregnant diabetic Wistar rats were fed a high-fat diet starting at the first gestational day. The
effect of the highfat diet on the growth of the female, her offspring, and the offspring's …

[HTML][HTML] Maternal high-fat diet impairs glucose metabolism, β-cell function and proliferation in the second generation of offspring rats

YH Huang, TT Ye, CX Liu, L Wang, YW Chen… - Nutrition & …, 2017 - Springer
Background This study aimed to assess the impact of perinatal high-fat (HF) diet in female
Sprague-Dawley rats (F0) on glucose metabolism and islet function in their early life of …

Exposure to intrauterine diabetes and post-natal high-fat diet: Effects on the endocrine pancreas of adult rat female pups

VS Barco, FQ Gallego, VG Paula, YK Sinzato, LL Cruz… - Life Sciences, 2022 - Elsevier
Aims To evaluate the morphological changes in the pancreatic islet cells of adult female
pups born to diabetic rats and fed a high-fat diet. Main methods Female Sprague-Dawley …

Maternal obesity and fetal programming: effects of a high-carbohydrate nutritional modification in the immediate postnatal life of female rats

M Srinivasan, C Dodds, H Ghanim… - American Journal …, 2008 - journals.physiology.org
Our earlier studies have shown that the artificial rearing of newborn rat pups [first generation
high carbohydrate (1-HC)] on an HC milk formula resulted in chronic hyperinsulinemia and …

Diet-induced obesity in the rat: a model for gestational diabetes mellitus

K Holemans, S Caluwaerts, L Poston… - American journal of …, 2004 - Elsevier
OBJECTIVES: Obesity is one of the most important risk factors for the development of
gestational diabetes mellitus (GDM). However, in obese women, it is difficult to disentangle …