Topographical cues mimicking the extracellular matrix (ECM) have demonstrated control
over a diverse range of cellular behaviours including: initial adhesion, migration, cell growth …

The physiological microenvironment of the stem cell niche, including the three factors of
stiffness, topography, and dimension, is crucial to stem cell proliferation and differentiation …

It is well known that biomaterial topography can exert a profound influence on various
cellular functions such as migration, polarization, and adhesion. With the development and …

Surface topography impacts on cell growth and differentiation, but it is not trivial to generate
defined surface structures and to assess the relevance of specific topographic parameters …

Chemical, mechanical, and topographic extracellular matrix (ECM) cues have been
extensively studied for their influence on cell behavior. These ECM cues alter cell adhesion …

It is well known that extracellular matrix stiffness can affect cell fate and change dynamically
during many biological processes. Existing experimental means for in situ matrix stiffness …

Nanotopography changes human mesenchymal stem cells (hMSC) from their shape to their
differentiation potential; however little is known about the underlying molecular mechanisms …

Within the heterogeneous tissue architecture, a comprehensive understanding of how cell
shapes regulate cytoskeletal mechanics by adjusting focal adhesions (FAs) signals to …

The ideal tissue engineering (TE) strategy for ligament regeneration should recapitulate the
bone–calcified cartilage–fibrocartilage–soft tissue interface. Aligned electrospun-fibers have …

Significant efforts have been directed to understanding the factors that influence the lineage
commitment of stem cells. This paper demonstrates that cell shape, independent of soluble …