Hypoxia describes limited oxygen availability at the cellular level. Myeloid cells are exposed
to hypoxia at various bodily sites and even contribute to hypoxia by consuming large …

Hematopoietic myeloblasts give rise to macrophages, dendritic cells, and neutrophils.
Circulating myeloid cells detect invading microbes using pattern recognition receptors and …

Hypoxia is a prominent characteristic of many acute or chronic inflammatory diseases, and
exerts significant influence on their progression. Macrophages and neutrophils are major …

Myeloid cells provide important functions in low oxygen (O 2) environments created by
pathophysiological conditions, including sites of infection, inflammation, tissue injury, and …

Significance: Oxygen deprivation (hypoxia) is a common feature at sites of inflammation.
Immune cells and all other cells present at the inflamed site have to adapt to these …

Hypoxia inducible factors (HIF1 and HIF2) have emerged as central regulators of the activity
of myeloid cells at inflammatory sites where O 2 is frequently limited. Novel insights in the …

The hypoxic response in cells and tissues is mediated by the family of hypoxia-inducible
factor (HIF) transcription factors; these play an integral role in the metabolic changes that …

In aerobic organisms, all cells have the capacity to respond to changes in oxygenation
through the stabilization and transcriptional activation of hypoxia-inducible factor (HIF). At …

Myeloid cells are key effectors of the innate immune response, and as such are often
required to migrate to, and function within, sites that are markedly hypoxic. To adapt to such …

Hypoxia-inducible factor (HIF) is a transcriptional activator that coordinates adaptive
responses to hypoxia. An increased activity is recognized in the majority of clinical relevant …