During infection with the human immunodeficiency virus type 1 (HIV-1), latent reservoirs are
established that circumvent full eradication of the virus by antiretroviral therapy (ART) and …

The latency phenomenon produced by human immunodeficiency virus (HIV‐1) prevents
viral clearance by current therapies, and consequently development of a cure for HIV‐1 …

One of the most explored therapeutic approaches aimed at eradicating HIV-1 reservoirs is
the “shock and kill” strategy which is based on HIV-1 reactivation in latently-infected cells …

Although antiretroviral therapies have improved the outlook of the HIV epidemic, they do not
provide a cure. The major barrier to development of a cure lies in the virus's ability to …

Despite the advances in Human Immunodeficiency Virus (HIV) treatment, the cure for all HIV
patients still poses a major challenge, which needs to be surpassed in the coming years …

HIV-1 establishes a latent reservoir in a subset of the cells it infects and there are no reliable
known biomarkers to distinguish this population from uninfected cells. Antiretroviral therapy …

Despite effective antiretroviral therapy, HIV-1 persistence in the latent reservoir remains the
major barrier to cure. Current strategies for HIV-1 eradication require either inducing HIV-1 …

Highly active antiretroviral therapy (HAART) has improved the outlook for the HIV epidemic,
but does not provide a cure. The proposed “shock‐and‐kill” strategy is directed at inducing …

The latent viral reservoir represents one of the major barriers of curing HIV. Focus on the
“kick and kill” approach, in which virus expression is reactivated then cells producing virus …

Despite the remarkable efficacy of antiretroviral therapy (ART) that dramatically reduced
morbidity and mortality among people with HIV-1 (PWH), the infection is uncurable due to …