An autosomal dominant mutation in the BRI2/ITM2B gene causes familial Danish dementia
(FDD). Analysis of FDDKI mice, a mouse model of FDD genetically congruous to the human …

Familial British Dementia (FBD) is caused by an autosomal dominant mutation in the
BRI2/ITM2B gene. FBDKI mice are a model of FBD that is genetically congruous to the …

An autosomal dominant mutation in the BRI2/ITM2B gene causes Familial Danish Dementia
(FDD). We have generated a mouse model of FDD, called FDD KI, genetically congruous to …

Background A mutation in the BRI2/ITM2b gene causes familial Danish dementia (FDD).
BRI2 is an inhibitor of amyloid-β precursor protein (APP) processing, which is genetically …

A mutation in the BRI2/ITM2b gene causes loss of BRI2 protein leading to familial Danish
dementia (FDD). BRI2 deficiency of FDD provokes an increase in amyloid‐β precursor …

Familial British dementia and familial Danish dementia are neurodegenerative disorders
caused by mutations in the gene integral membrane protein 2B (ITM2b) encoding BRI2 …

Mutations in integral membrane protein 2B (ITM2b/BRI2) gene cause familial British and
Danish dementia (FBD and FDD), autosomal dominant disorders characterized by …

Mutations in BRI2/ITM2b genes cause Familial British and Danish Dementias (FBD and
FDD), which are pathogenically similar to Familial Alzheimer Disease (FAD). BRI2 inhibits …

Analyses of the biologic effects of mutations in the BRI2 (ITM2b) and the amyloid β precursor
protein (APP) genes support the hypothesis that cerebral accumulation of amyloidogenic …

Alzheimer disease (AD), the most common senile dementia, is characterized by amyloid
plaques, vascular amyloid, neurofibrillary tangles, and progressive neurodegeneration …