The aim of our study was to investigate the osteoinductive potential of a titanium (Ti) surface
with nanotopography, using mesenchymal stem cells (MSCs) and the mechanism involved …

Topographical modifications of titanium (Ti) at the nanoscale level generate surfaces that
regulate several signaling pathways and cellular functions, which may affect the process of …

The major role of integrins is to mediate cell adhesion but some of them are involved in the
osteoblasts–titanium (Ti) interactions. In this study, we investigated the participation of …

Nanotopographical cues of bone implant surface has direct influences on various cell types
during the establishment of osseointegration, a prerequisite of implant bear-loading. Given …

Several studies have shown the positive effects of Ti either with nanotopography or coated
with collagen on osteoblast differentiation. Thus, we hypothesized that the association of …

Wnt/β-catenin signal transduction is involved in the homeostatic control of bone mass. It is
well established that a titanium surface with nanotopography (Ti-Nano) favors osteoblast …

Background: The events of bone formation and osteoblast/titanium (Ti) interactions may be
affected by Hedgehog and Notch signalling pathways. Herein, we investigated the effects of …

We aimed at evaluating the effect of titanium (Ti) with nanotopography (Nano) on the
endogenous expression of BMP‐2 and BMP‐4 and the relevance of this process to the …

Introduction Fabricating nanostructured surface topography represents the mainstream
approach to induce osteogenesis for the next-generation bone implant. In the past, the bone …

Abstract Micro/nano-topography (MNT) is an important factor affecting cell response. Earlier
studies using titania (TiO 2) nanotube as a model of MNT found that they mediated the …