Compartmental models: limitation for measurement of CBF with PET

KB Larson, ME Raichle - J. Nucl. Med.;(United States), 1985 - osti.gov
All tracer kinetic models currently employed with positron emission tomography (PET), are
based on compartmental assumptions; that is, tracer transport can be interpreted in terms of …

Estimation of ischemic cerebral blood flow using [15O] water and PET without arterial blood sampling

J Löttgen, U Pietrzyk, K Herholz, K Wienhard… - … Brain Imaging with …, 1998 - Elsevier
Measurements of regional cerebral blood flow (CBF) using [15 O] H 2 O and positron
emission tomography (PET) require the determination of the input function by arterial blood …

A Noninvasive Approach to Quantitative Functional Brain Mapping with H215O and Positron Emission Tomography

PT Fox, MA Mintun, ME Raichle… - Journal of Cerebral …, 1984 - journals.sagepub.com
Positron emission tomographic (PET) measurements of regional cerebral blood flow (rCBF)
with intravenously administered 15O-labeled water and an adaptation of the Kety …

Uncoupling of flow and metabolism in infarcted tissue

T Jones, RJS Wise, RSJ Frackowiak, JM Gibbs… - Functional Mapping of …, 1985 - Springer
In order to study the relationship between regional cerebral blood flow and metabolism, it is
necessary to measure these entities of tissue function independently. The use of gamma-ray …

Can ROI methodology/normalised tissue activities be used instead of absolute blood flow measurements in the brain?

DC Costa - European Journal of Nuclear Medicine & …, 2002 - search.ebscohost.com
Examines whether the normalized tissue activities can be used instead of absolute blood
flow measurements in the brain. Main methods for investigation of cerebral circulation; …

[PDF][PDF] Evaluation of a potential generator-produced PET tracer for cerebral perfusion imaging: single-pass cerebral extraction measurements and imaging with …

CJ Mathias, MJ Welch, ME Raichle… - Journal of Nuclear …, 1990 - Soc Nuclear Med
Department ofRadiology, Washington University School ofMedicine, St. Louis, Missouri;
MURR University ofMissouri, Columbia, Missouri; and School ofPharmacy, Purdue …

Rapid measurement of regional cerebral blood flow in the baboon using15O-labelled water and dynamic positron emission tomography

E Pinard, B Mazoyer, B Verrey, S Pappata… - Medical and Biological …, 1993 - Springer
The sensitivity and reproducibility of rapid measurements of regional cerebral flow (rCBF)
using a bolus injection of H 2 15 O and dynamic positron emission tomography (PET) were …

Counts vs. Flow: When Does It Matter?

RD Hichwa, DS O'Leary, LLB Ponto, S Arndt… - Quantification of Brain …, 1996 - iro.uiowa.edu
In this chapter, region of interest (ROI) methods are evaluated along with function of interest
(FOI) methods to determine when and if quantitative flow values (arterial input function …

Error analysis of the integrated projection technique (IP) and the weighted integration method (WI) for measurement of local cerebral blood flow (LCBF) with positron …

RE Carson, SC Huang - J. Nucl. Med.;(United States), 1984 - osti.gov
The effects of oversimplifications in the Kety-Schmidt model for measuring LCBF with PET
and bolus injections of 0-15 water has been studied by computer simulation. Flow estimates …

Quantitative Measurements of Cerebral Blood Flow Using SPECT and [99mTc]-d,l-HM-PAO Compared to Xenon-133

AR Andersen, HH Friberg, JF Schmidt… - Journal of Cerebral …, 1988 - journals.sagepub.com
The uptake and retention in a 2 cm thick brain section was recorded serially by SPECT after
iv injection of [99mTc]–d, l-HM-PAO (HM-PAO). In 16 patients, the fraction of the …