Hypothalamic kisspeptin is a known principal activator of gonadotropin-releasing hormone
neurons and governs the hypothalamic-pituitary-gonadal axis. Previous reports have shown …

Hypothalamic kisspeptin plays a pivotal role in the regulation of the hypothalamic-pituitary-
gonadal axis by stimulating gonadotropin-releasing hormone (GnRH) release into the portal …

Kisspeptin (Kiss1) is an amidated neurohormone that belongs to the RF-amide peptide
family, which has a key role in the control of reproduction. Specifically, kisspeptin regulates …

Kisspeptin has been shown to stimulate prolactin secretion. We investigated whether
kisspeptin acts through the Kiss1 receptor (Kiss1r) to regulate dopamine and prolactin …

Recent, compelling evidence indicates that kisspeptins, the products of KiSS‐1 gene, and
their receptor GPR54, represent key elements in the neuroendocrine control of reproduction …

Kisspeptin signaling through its receptor, Kiss1R, is crucial for many reproductive functions
including puberty, sex steroid feedback, and overall fertility. Although the importance of …

Kisspeptins are products of the KiSS-1 gene, which bind to a G protein-coupled receptor
known as GPR54. Mutations or targeted disruptions in the GPR54 gene cause …

Since the stimulatory effect of kisspeptin on gonadotropin secretion is blocked by a GnRH
antagonist, it has been suggested that the effect of kisspeptin is manifest exclusively at the …

The Kiss1 gene encodes a 145-amino acid pre-peptide, kisspeptin, which is cleaved into
smaller peptides of 54, 14, 13, and 10 amino acids. This chapter reviews in detail the effects …

Prolactin (PRL) is tonically inhibited by dopamine (DA) released from neurons in the arcuate
and periventricular nuclei. Kisspeptin plays a pivotal role in LH regulation. In rodents …