Increased interest in the underlying pathogenesis of primary lateral sclerosis (PLS) and its
relationship to amyotrophic lateral sclerosis (ALS) has corresponded to a growing number of …

MRI and PET studies in ALS have consistently shown patterns of functional and structural
changes considered to be the pathological signature of the disease. The constant advance …

Background Brainstem pathology is a hallmark feature of ALS, yet most imaging studies
focus on cortical grey matter alterations and internal capsule white matter pathology …

Neuroimaging allows investigating the extent of neurological systems degeneration in
amyotrophic lateral sclerosis (ALS). Advanced MRI methods can detect changes related to …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease involving upper and
lower motor neurons, extra-motor neurons, microglia and astrocytes. The neurodegenerative …

Primary lateral sclerosis (PLS) has been traditionally viewed as a distinct upper motor
neuron condition (UMN) but is increasingly regarded as a sub-phenotype within the …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects motor
neurons in the cerebral cortex, brainstem, and spinal cord, brain regions in which …

Background Primary lateral sclerosis (PLS) is a low incidence motor neuron disease which
carries a markedly better prognosis than amyotrophic lateral sclerosis (ALS). Despite …

Primary lateral sclerosis (PLS) has been regarded as a rare, extreme form of amyotrophic
lateral sclerosis (ALS). Like ALS, it is a clinical diagnosis without established biomarkers …

Introduction: Several neuroimaging techniques have been used to define in vivo markers of
pathological alterations underlying amyotrophic lateral sclerosis (ALS). Growing evidence …