Structural MRI correlates of amyotrophic lateral sclerosis progression
J Senda, N Atsuta, H Watanabe… - Journal of Neurology …, 2017 - jnnp.bmj.com
Purpose Amyotrophic lateral sclerosis (ALS) presents with varying degrees of brain
degeneration that can extend beyond the corticospinal tract (CST). Furthermore, the clinical …
degeneration that can extend beyond the corticospinal tract (CST). Furthermore, the clinical …
Positron emission tomography (PET)–its potential to provide surrogate markers in ALS
Positron emission tomography (PET) has enabled us to study the human brain with
unrivalled sensitivity, and has already established its place in the research of neurological …
unrivalled sensitivity, and has already established its place in the research of neurological …
Widespread microstructural white matter involvement in amyotrophic lateral sclerosis: a whole-brain DTI study
M Cirillo, F Esposito, G Tedeschi… - American journal …, 2012 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: The extensive application of advanced MR imaging
techniques to the study of ALS has undoubtedly improved our knowledge of disease …
techniques to the study of ALS has undoubtedly improved our knowledge of disease …
Extra-motor cerebral changes and manifestations in primary lateral sclerosis
E Finegan, SLH Shing, RH Chipika, KM Chang… - Brain imaging and …, 2021 - Springer
Primary lateral sclerosis (PLS) is classically considered a 'pure'upper motor neuron disorder.
Motor cortex atrophy and pyramidal tract degeneration are thought to be pathognomonic of …
Motor cortex atrophy and pyramidal tract degeneration are thought to be pathognomonic of …
Imaging: Mrs/mri/pet/spect: Summary
Sensitive and specific surrogate measures of disease progression are most likely to be
based on direct measures of selective neuronal damage. The 'classical'view of selective …
based on direct measures of selective neuronal damage. The 'classical'view of selective …
Mind the gap: the mismatch between clinical and imaging metrics in ALS
E Verstraete, MR Turner, J Grosskreutz… - … lateral sclerosis and …, 2015 - Taylor & Francis
Advanced magnetic resonance imaging (MRI) techniques hold the promise to capture upper
motor neuron loss and extramotor brain changes in amyotrophic lateral sclerosis (ALS) and …
motor neuron loss and extramotor brain changes in amyotrophic lateral sclerosis (ALS) and …
[HTML][HTML] Imaging and clinical data indicate considerable disease burden in 'probable'PLS: Patients with UMN symptoms for 2–4 years
E Finegan, WF Siah, SLH Shing, RH Chipika… - Data in brief, 2020 - Elsevier
Primary lateral sclerosis (PLS) is an adult-onset upper motor neuron disease manifesting in
progressive spasticity and gradually resulting in considerably motor disability. In the …
progressive spasticity and gradually resulting in considerably motor disability. In the …
Longitudinal structural changes in ALS: a three time-point imaging study of white and gray matter degeneration
P Bede, O Hardiman - Amyotrophic Lateral Sclerosis and …, 2018 - Taylor & Francis
Background: Cross-sectional imaging studies offer valuable pathological insights into the
neurodegenerative changes of amyotrophic lateral sclerosis. However, clinical trials urgently …
neurodegenerative changes of amyotrophic lateral sclerosis. However, clinical trials urgently …
[HTML][HTML] Cross-sectional and longitudinal assessment of the upper cervical spinal cord in motor neuron disease
HK van der Burgh, HJ Westeneng, JM Meier… - NeuroImage: Clinical, 2019 - Elsevier
Background Amyotrophic lateral sclerosis (ALS) is a progressive neuromuscular disease
characterized by both upper and lower motor neuron degeneration. While neuroimaging …
characterized by both upper and lower motor neuron degeneration. While neuroimaging …
Combining structural and metabolic markers in a quantitative MRI study of motor neuron diseases
A Canna, F Trojsi, F Di Nardo… - Annals of Clinical …, 2021 - Wiley Online Library
Objective To assess the performance of a combination of three quantitative MRI markers
(iron deposition, basal neuronal metabolism, and regional atrophy) for differential diagnosis …
(iron deposition, basal neuronal metabolism, and regional atrophy) for differential diagnosis …