Amyotrophic lateral sclerosis (ALS) is an incurable and progressively fatal
neurodegenerative disease that manifests with distinct clinical phenotypes, which are seen …

Background The results of recent diffusion tensor imaging (DTI) studies on amyotrophic
lateral sclerosis (ALS) are inconclusive and controversial. We performed a voxel-based …

Amyotrophic lateral sclerosis (ALS) is primarily characterized by progressive loss of motor
neurons, although there is marked phenotypic heterogeneity between cases. Typical, or …

Background and aims Considering the great heterogeneity of amyotrophic lateral sclerosis
(ALS), the identification of accurate prognostic predictors is fundamental for both the clinical …

Objective To determine whether proton magnetic resonance spectroscopy (1H-MRS) can
detect neurochemical changes in amyotrophic lateral sclerosis (ALS) associated with …

Background Amyotrophic lateral sclerosis (ALS) is a fatal, rapidly progressive
neurodegenerative disease that mainly affects the motor system. A number of potentially …

Objective To evaluate MRI-based parameters as biomarkers of Amyotrophic Lateral
Sclerosis (ALS) progression. Methods Twenty-seven patients and 27 controls performed two …

Background Widespread cortical atrophy in Amyotrophic Lateral Sclerosis (ALS) has been
described in neuropathological studies. The presence of cortical atrophy in conventional …

Objective Advanced neuroimaging techniques may offer the potential to monitor disease
spreading in amyotrophic lateral sclerosis (ALS). We aim to investigate brain functional and …

Introduction: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that causes
progressive muscle weakness and disability, eventually leading to death. Heterogeneity of …