Physiologic, morphologic, biochemical, and immunologic methods have been used to study
cholinergic and adrenergic regulation of airway submucosal gland secretion. Using a newly …

We developed methods to study secretions from airway submucosal glands in vivo:
micropipettes with tips specially designed to seal around individual gland duct openings …

With evolution, animals moved from. water t? land wi consequent air breathing. Inhalation of
air contaminated with viruses, bacterial, and other particulate material led to protective …

This historical article provides a comprehensive review of early research on the structure
and function of airway submucosal glands. The literature before 1950 or so, is virtually …

We describe a micropipette method for obtaining secretions from single submucosal gland
ducts in vivo in cat tracheas. The secretory rate of 65 glands sampled under basal conditions …

The output of secretions from the airway submucosal glands is regulated by vagal efferent
nerves. Stimulation of cough receptors increases mucus output reflexly via the vagus nerves …

Cholinergic Influences There appears to be general agreement that mucus secretion by
submucosal glands of the airways is stimulated by cholinergic agents in vitro and in vivo …

We used our microcollection technique to study the effect of mechanical stimulation of the
larynx on tracheobronchial gland secretion. The basal secretory rate of 8 glands in 5 cats …

Airway submucosal glands occupy a substantial volume of the large conducting airways and
are regulated by vagal muscarinic nerves, alpha-and beta-adrenergic nerves, and …

From &e Cardiovascular Research Institute and Departments of Medbim and Physiology,
University of California. Receiv+ d for publication March 16, 198 1. Acce for publication …