[HTML][HTML] Functional characterization, structural basis, and protein engineering of a rare flavonoid 2′-O-glycosyltransferase from Scutellaria baicalensis

Z Wang, X Du, G Ye, H Wang, Y Liu, C Liu, F Li… - … Pharmaceutica Sinica B, 2024 - Elsevier
Glycosylation is an important post-modification reaction in plant secondary metabolism, and
contributes to structural diversity of bioactive natural products. In plants, glycosylation is …

Highly Promiscuous Flavonoid 3-O-Glycosyltransferase from Scutellaria baicalensis

Z Wang, S Wang, Z Xu, M Li, K Chen, Y Zhang… - Organic …, 2019 - ACS Publications
A highly regio-specific and donor-promiscuous 3-O-glycosyltransferase, Sb3GT1
(UGT78B4), was discovered from Scutellaria baicalensis. Sb3GT1 could accept five sugar …

Identification of a Flavonoid Glucosyltransferase Involved in 7-OH Site Glycosylation in Tea plants (Camellia sinensis)

X Dai, J Zhuang, Y Wu, P Wang, G Zhao, Y Liu… - Scientific reports, 2017 - nature.com
Flavonol glycosides, which are often converted from aglycones in a process catalyzed by
UDP-glycosyltransferases (UGTs), play an important role for the health of plants and …

Mining of UDP‐glucosyltrfansferases in licorice for controllable glycosylation of pentacyclic triterpenoids

L Zhang, S Ren, X Liu, X Liu, F Guo… - Biotechnology and …, 2020 - Wiley Online Library
Pentacyclic triterpenoids have wide applications in the pharmaceutical industry. The precise
glucosylation at C‐3 OH of pentacyclic triterpenoids mediated by uridine 5'‐diphospho …

Molecular cloning and biochemical characterization of a new coumarin glycosyltransferase CtUGT1 from Cistanche tubulosa

X Xu, Y Yan, W Huang, T Mo, X Wang, J Wang, J Li… - Fitoterapia, 2021 - Elsevier
UDP-glycosyltransferases (UGTs) are an important and functionally diverse family of
enzymes involved in secondary metabolite biosynthesis. Coumarin is one of the most …

Efficient O-glycosylation of triterpenes enabled by protein engineering of plant glycosyltransferase UGT74AC1

J Li, J Yang, S Mu, N Shang, C Liu, Y Zhu, Y Cai… - ACS …, 2020 - ACS Publications
Triterpene O-glycosylation has attracted significant interest from the pharmaceutical industry
as a valuable means for drug design and development. Plant glycosyltransferases, which …

Advances in plant flavonoids UDP-glycosyltransferase

Y YAO, J GU, C SUN, G SHEN… - Biotechnology …, 2022 - biotech.aiijournal.com
Flavonoids are important natural products in plants and usually exist in the form of
glycosides. Uridine diphosphate glycosyltransferases (UGTs) can modify flavonoids to form …

Plant UDP-glycosyltransferases in flavonoids biosynthesis.

L Xie, C Ren, B Zhang, X Changjie, X Li - 2019 - cabidigitallibrary.org
Flavonoids are important polyphenols for human diet and ornamental horticulture.
Flavonoids attract attention for their wide range of biological activities and important …

Identification of a permissive glycosyltransferase UGT73AC11 for flavonoids glycosylation

X Liu, W Xu, J Li, X Feng, C Li - Biochemical Engineering Journal, 2024 - Elsevier
Flavonoids, natural products derived from plants, have shown promising potential in food
and medicine. These compounds are commonly found in the form of glycosides, which …

Directed evolution of a plant glycosyltransferase for chemo-and regioselective glycosylation of pharmaceutically significant flavonoids

Z Wen, ZM Zhang, L Zhong, J Fan, M Li, Y Ma… - ACS …, 2021 - ACS Publications
Glycosyltransferases have attracted increasing interest for the ability to construct
glycosylated molecules in a facile way. However, promiscuous chemoselectivity and poor …