Innate viral sensor MDA5 and coxsackievirus interplay in type 1 diabetes development
SI Blum, HM Tse - Microorganisms, 2020 - mdpi.com
Type 1 diabetes (T1D) is a polygenic autoimmune disease characterized by immune-
mediated destruction of insulin-producing β-cells. The concordance rate for T1D in …
mediated destruction of insulin-producing β-cells. The concordance rate for T1D in …
Reduced Expression of the MDA5 Gene IFIH1 Prevents Autoimmune Diabetes
PJ Lincez, I Shanina, MS Horwitz - Diabetes, 2015 - Am Diabetes Assoc
Although it is widely accepted that type 1 diabetes (T1D) is the result of the autoimmune
destruction of insulin-producing β-cells in the pancreas, little is known about the events …
destruction of insulin-producing β-cells in the pancreas, little is known about the events …
Increased expression of viral sensor MDA5 in pancreatic islets and in hormone-negative endocrine cells in recent onset type 1 diabetic donors
L Nigi, N Brusco, GE Grieco, D Fignani… - Frontiers in …, 2022 - frontiersin.org
The interaction between genetic and environmental factors determines the development of
type 1 diabetes (T1D). Some viruses are capable of infecting and damaging pancreatic β …
type 1 diabetes (T1D). Some viruses are capable of infecting and damaging pancreatic β …
[HTML][HTML] MDA5-dependent responses contribute to autoimmune diabetes progression and hindrance
SI Blum, JP Taylor, JM Barra, AR Burg, Q Shang… - JCI insight, 2023 - ncbi.nlm.nih.gov
Abstract Type 1 diabetes (T1D) is an autoimmune disease resulting in pancreatic β cell
destruction. Coxsackievirus B3 (CVB3) infection and melanoma differentiation-associated …
destruction. Coxsackievirus B3 (CVB3) infection and melanoma differentiation-associated …
RNA sensor–induced type I IFN prevents diabetes caused by a β cell–tropic virus in mice
Viral infections have been linked to the onset of type I diabetes (T1D), with viruses
postulated to induce disease directly by causing β cell injury and subsequent release of …
postulated to induce disease directly by causing β cell injury and subsequent release of …
The innate immune receptor MDA 5 limits rotavirus infection but promotes cell death and pancreatic inflammation
Y Dou, HCH Yim, CD Kirkwood, BRG Williams… - The EMBO …, 2017 - embopress.org
Melanoma differentiation‐associated protein 5 (MDA 5) mediates the innate immune
response to viral infection. Polymorphisms in IFIH1, the gene coding for MDA 5, correlate …
response to viral infection. Polymorphisms in IFIH1, the gene coding for MDA 5, correlate …
Effects of Type 1 Diabetes-Associated IFIH1 Polymorphisms on MDA5 Function and Expression
BM Looney, CQ Xia, P Concannon, DA Ostrov… - Current diabetes …, 2015 - Springer
Recent evidence has highlighted the role of the innate immune system in type 1 diabetes
(T1D) pathogenesis. Specifically, aberrant activation of the interferon response prior to …
(T1D) pathogenesis. Specifically, aberrant activation of the interferon response prior to …
TLR7/9 versus TLR3/MDA5 signaling during virus infections and diabetes
M Swiecki, SA McCartney, Y Wang… - Journal of leukocyte …, 2011 - academic.oup.com
ABSTRACT IFN-I are pleiotropic cytokines that impact innate and adaptive immune
responses. In this article, we discuss TLR7/9 versus TLR3/MDA5 signaling in antiviral …
responses. In this article, we discuss TLR7/9 versus TLR3/MDA5 signaling in antiviral …
[HTML][HTML] Melanoma differentiation-associated protein-5 (MDA-5) limits early viral replication but is not essential for the induction of type 1 interferons after …
Coxsackievirus infections are associated with severe diseases such as myocarditis,
meningitis and pancreatitis. To study the contribution of the intracellular viral sensor …
meningitis and pancreatitis. To study the contribution of the intracellular viral sensor …
An IFIH1 gene polymorphism associated with risk for autoimmunity regulates canonical antiviral defence pathways in Coxsackievirus infected human pancreatic islets
The IFIH1 gene encodes the pattern recognition receptor MDA5. A common polymorphism
in IFIH1 (rs1990760, A946T) confers increased risk for autoimmune disease, including type …
in IFIH1 (rs1990760, A946T) confers increased risk for autoimmune disease, including type …