Pectin-tannic acid nano-complexes promote the delivery and bioactivity of drugs in pancreatic cancer cells

SS Chauhan, AB Shetty, E Hatami, P Chowdhury… - Pharmaceutics, 2020 - mdpi.com
Pancreatic cancer (PanCa) is a lethal disease. Conventional chemotherapies for PanCa
offer severe systemic toxicities. Thus, the development of a successful nanomedicine-based …

In vitro and in vivo evaluation of pectin-based nanoparticles for hepatocellular carcinoma drug chemotherapy

CY Yu, YM Wang, NM Li, GS Liu, S Yang… - Molecular …, 2014 - ACS Publications
The fabrication and evaluation of a natural pectin-based drug delivery system are reported
in this study. The drug delivery system displays specific active targeting ability to …

Augmentation of anti–tumour activity of cisplatin by pectin nano–conjugates in B–16 mouse model: pharmacokinetics and in–vivo biodistribution of radio–labelled …

AK Verma, A Chanchal… - International journal of …, 2012 - inderscienceonline.com
Nanoconjugates have matured from simple devices to multifunctional, biodegradable, non–
toxic and non–immunogenic constructs, capable of delivering synergistically functioning …

In vitro anticancer activity of doxorubicin-loading pectin nanoparticles

G Tian, Z Guifang, Y Qiumian… - Journal of …, 2016 - lawarencepress.com
By using pectin (PEC) as carrier material and doxorubicin (DOX) as a model drug, the blank
PEC nanoparticles (PEC-NPs) and the DOX-loading PEC nanoparticles (DOX-PEC-NPs) …

Self-Assembling pH-Responsive Nanoparticle Platform Based on Pectin–Doxorubicin Conjugates for Codelivery of Anticancer Drugs

Y Tao, D Zheng, J Zhao, K Liu, J Liu, J Lei, L Wang - ACS omega, 2021 - ACS Publications
Pharmaceutical science based on biological nanotechnology is developing rapidly in
parallel with the development of nanomaterials and nanotechnology in general. Pectin is a …

Self-assembled folic acid-targeted pectin-multi-arm polyethylene glycol nanoparticles for tumor intracellular chemotherapy

Y Liu, T Kong, Z Yang, Y Zhang, J Lei, P Zhao - ACS omega, 2021 - ACS Publications
Ursolic acid is widely used as an effective anticancer drug for the treatment of various
cancers. However, its poor water solubility, short circulation time in vivo, and lack of targeting …

Pharmacokinetics and biodistribution of negatively charged pectin nanoparticles encapsulating paclitaxel

AK Verma, A Kumar - Cancer nanotechnology, 2013 - Springer
Pectin, a naturally occurring biopolymer has been found to have increasing applications in
the pharmaceutical and biotechnology industry. Sugars with their three-dimensional …

Pectin nanoparticle enhances cytotoxicity of methotrexate against hepG2 cells

C Chittasupho, M Jaturanpinyo, S Mangmool - Drug delivery, 2013 - Taylor & Francis
Objective: This work has aimed to develop methotrexate-conjugated pectin nanoparticle for
delivering a cytotoxic drug to hepatic cancer cell. Methods: Methotrexate was conjugated to …

A novel self-assembled nanoparticle platform based on pectin-eight-arm polyethylene glycol-drug conjugates for co-delivery of anticancer drugs

Y Liu, K Liu, X Li, S Xiao, D Zheng, P Zhu, C Li… - Materials Science and …, 2018 - Elsevier
The application of non-toxic carriers to increase drug loading, multi-drug delivery, and
extremely small size of nano-drugs to construct a tremendous transmission system is the …

Cetuximab-conjugated chitosan-pectinate (modified) composite nanoparticles for targeting colon cancer

R Sabra, N Billa, CJ Roberts - International journal of pharmaceutics, 2019 - Elsevier
In the present study, we successfully developed a cetuximab-conjugated modified citrus
pectin-chitosan nanoparticles for targeted delivery of curcumin (Cet-MCPCNPs) for the …