Adolescence is a transitional period during development that is associated with a greater
likelihood of addiction to drugs than any other age. One possibility for this observation is that …

The periadolescent period in the rat is characterized by alterations in novelty seeking and
exploratory behavior, as well as changes in the behavioral responsiveness to many drugs of …

Human and animal laboratory studies show that adolescents and adults respond differently
to drugs and that drug administration during adolescence leads to different behavioral …

Rationale Drug addiction is a multifactorial disorder resulting from an interaction between
genetic and environmental factors, and negative and positive environmental conditions may …

Relapse to drug use following prolonged periods of abstinence results, in part, from the
ability of contextual cues paired previously with self-administered drug to elicit drug craving …

Rationale Age of initial exposure to addictive substances is inversely proportional to risk of
developing drug dependence. There is debate, however, as to whether intake at a young …

To explore the way in which drugs act to reinstate drug-seeking behavior, we studied drug-
induced reinstatement of a cocaine-induced conditioned place preference (CPP). In a series …

Cocaine abusers may experience drug craving upon exposure to environmental contexts
where cocaine was experienced. The dorsal hippocampus (DHC) is important for contextual …

Conditioned place preference (CPP) with both visual and tactile cues, hyperactivity, and
stereotypies produced by d-amphetamine (1–10 mg/kg ip, single dose) were studied in CD …

As addiction is increasingly formulated as a developmental disorder, identifying how early
developmental exposures influence later responses to drugs of abuse is important to our …