Repeated association of drugs of abuse with context leads to long-lasting behavioral
responses that reflect reward-controlled learning and participate in the establishment of …

Rationale and objectives Although onset of drug use during adolescence appears to
increase long-term vulnerability to drug dependence in humans, relatively little is known …

Repeated exposure to drugs of abuse produces forms of experience-dependent plasticity
including behavioral sensitization. Although a single exposure to many addicting …

There is considerable interest in elucidating neurocognitive mechanisms of cocaine
addiction. This report focuses on the hippocampal memory system. Using food reward, two …

The powerful, long-lasting association between the rewarding effects of a drug and
contextual cues associated with drug administration can be studied using conditioned place …

Learned associations between drugs and the places they are used are critical to the
development of drug addiction. Contextual conditioning has long been studied in animals as …

It has been speculated that an individual's response to novelty is a reliable predictor of its
vulnerability to develop addiction. However, the relationships between response to novelty …

The development of drug-seeking habits is implicated in the transition from recreational drug
use to addiction. Using a drug seeking/taking chained schedule of intravenous cocaine self …

In humans, adolescent exposure to illicit drugs predicts the onset of adult drug abuse and
suggests that early drug use potentiates vulnerability to drug addiction. Cocaine conditioned …

Previous work has demonstrated an important role for adrenergic receptors in memory
processes in fear and drug conditioning paradigms. Recent studies have also demonstrated …