Exposure to a cocaine‐paired context increases the propensity for relapse in cocaine users
and prompts cocaine‐seeking behavior in rats. According to the reconsolidation hypothesis …

A key aspect of substance abuse is that drug taking often occurs in a specific context. As a
consequence, exposure to drug‐associated contexts can trigger cravings and relapse, even …

Several reports in the literature suggested that environmental influences which are reflected
in the social housing conditions of the rat may play a role in the expression of individual …

Human drug addiction is a complex disorder, in which exogenous substances are able to
recruit and maintain behaviors involved in drug taking. Many drugs that are addictive in …

Cocaine is a potent stimulant drug, but its stimulant effects can be substantially modulated
by environmental novelty versus familiarity. In this report, we varied exposures to a novel …

Dysfunctional learning systems are thought to be central to the pathogenesis of and impair
recovery from addictions. The functioning of the brain circuits for episodic memory or …

The study addressed two issues. First, we examined the effectiveness of heroin as a
conditioning agent in a preferred environment using a place preference paradigm. Four …

These studies examined the ability of a conditioned stimulus previously paired with
footshock to reinstate cocaine-induced conditioned place preference. Male rats were given …

Individual differences in locomotor responses to novelty and psychostimulants, and
sensitization following repeated drug exposure, predict increased sensitivity to the …

The spatial memory of adult rats prenatally exposed to cocaine and that of control offspring
was assessed using the Morris water maze. Offspring were derived from Sprague Dawley …