The human airway is protected by an efficient innate defense mechanism that requires
healthy secretion of airway surface liquid (ASL) to clear pathogens from the lungs. Most of …

Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator
(CFTR) protein, an epithelial chloride channel expressed in the airways, pancreas, testis …

Malfunction of airway submucosal glands contributes to the pathology of cystic fibrosis (CF),
and cell cultures of CF human airway glands show defects in Cl− and water transport …

While pathological and clinical data suggest that small airways are involved in early cystic
fibrosis (CF) lung disease development, little is known about how the lack of cystic fibrosis …

Airway submucosal glands are important sites of cystic fibrosis transmembrane conductance
regulator (CFTR) chloride (Cl−) channel expression and fluid secretion in the airway …

The airways are lined with a film of liquid about 10 µm deep that is in two layers. Around the
cilia is the watery periciliary sol. Over this is a mucous blanket that traps inhaled particles …

A controversial hypothesis pertaining to cystic fibrosis (CF) lung disease is that the CF
transmembrane conductance regulator (CFTR) channel fails to inhibit the epithelial Na+ …

Airway submucosal glands are sites of high expression of the cystic fibrosis transmembrane
conductance regulator (CFTR) Cl− channel and contribute to fluid homeostasis in the lung …

Submucosal glands (SMGs) protect lungs but can also contribute to disease. For example, in
cystic fibrosis (CF), SMGs produce abnormal mucus that disrupts mucociliary transport. CF is …

Cystic fibrosis (CF) results from mutations that disrupt CF transmembrane conductance
regulator (CFTR), an anion channel found mainly in apical membranes of epithelial cells. CF …