Hepatic disease accounts for approximately 2 million deaths/year worldwide. Liver fibrosis,
as the last stage of numerous chronic liver diseases, is one of the most relevant prognostic …

With great advancements in the therapeutic modalities used for the treatment of chronic liver
diseases, the accurate assessment of liver fibrosis is a vital need for successful …

Hepatic fibrosis is the final common pathway for a multitude of liver injuries. Viral-, immune-,
or toxin-mediated liver injuries all result in expansion of the extracellular matrix with …

Chronic liver diseases of differing etiologies are among the leading causes of mortality and
morbidity worldwide. Establishing accurate staging of liver disease is very important for …

Often regarded as the gold standard for fibrosis assessment, liver biopsy does carry
associated risks given its invasive nature. Moreover, liver biopsy is not a true gold standard …

The accurate staging of liver fibrosis in chronic liver diseases, especially the early diagnosis
of liver cirrhosis, is crucial for prognostic assessment of the course of the disease. The …

As novel therapies for liver fibrosis evolve, non‐invasive measurement of liver fibrosis will be
required to help manage patients with chronic liver disease. Although liver biopsy is the …

Hepatic fibrosis is the final common pathway for many different liver insults. Originally
considered to be irreversible, hepatic fibrosis is now known to be a dynamic process with a …

Liver fibrosis is a potentially reversible response to hepatic insults, triggered by different
chronic diseases most importantly viral hepatitis, alcoholic, and nonalcoholic fatty liver …

Hepatic fibrogenesis may gradually result to cirrhosis due to the accumulation of
extracellular matrix components as a response to liver injury. Thus, therapeutic decisions in …