The utilization of cell-penetrating peptides in the intracellular delivery of viral nanoparticles

J Váňová, A Hejtmánková, MH Kalbáčová… - Materials, 2019 - mdpi.com
Viral particles (VPs) have evolved so as to efficiently enter target cells and to deliver their
genetic material. The current state of knowledge allows us to use VPs in the field of …

[HTML][HTML] Delivery of nucleic acids and nanomaterials by cell-penetrating peptides: opportunities and challenges

YW Huang, HJ Lee, LM Tolliver… - BioMed research …, 2015 - hindawi.com
Many viral and nonviral systems have been developed to aid delivery of biologically active
molecules into cells. Among these, cell-penetrating peptides (CPPs) have received …

[HTML][HTML] Potential of cell-penetrating peptides (CPPs) in delivery of antiviral therapeutics and vaccines

I Sadeghian, R Heidari, S Sadeghian, MJ Raee… - European Journal of …, 2022 - Elsevier
Viral infections are a great threat to human health. Currently, there are no effective vaccines
and antiviral drugs against the majority of viral diseases, suggesting the need to develop …

Cell-penetrating peptide-mediated nanovaccine delivery

J Jiang - Current Drug Targets, 2021 - ingentaconnect.com
Vaccination with small antigens, such as proteins, peptides, or nucleic acids, is used to
activate the immune system and trigger the protective immune responses against a …

Next-generation viral nanoparticles for targeted delivery of therapeutics: Fundamentals, methods, biomedical applications, and challenges

JS Tan, MNB Jaffar Ali, BK Gan… - Expert Opinion on Drug …, 2023 - Taylor & Francis
ABSTRACT Introduction Viral nanoparticles (VNPs) are virus-based nanocarriers that have
been studied extensively and intensively for biomedical applications. However, their clinical …

VirPorters: Insights into the action of cationic and histidine-rich cell-penetrating peptides

J Váňová, B Číhařová, A Hejtmánková… - International Journal of …, 2022 - Elsevier
The utilization of nanoparticles for the intracellular delivery of theranostic agents faces one
substantial limitation. Sequestration in intracellular vesicles prevents them from reaching the …

Peptide nanoparticles for oligonucleotide delivery

T Lehto, K Ezzat, Ü Langel - … in molecular biology and translational science, 2011 - Elsevier
In the past two decades, different methods have emerged for intervention with gene
expression, which can be generally referred to as gene therapy. Oligonucleotides (ONs) and …

Influence of cell-penetrating peptides on the activity and stability of virus-based nanoparticles

J Váňová, A Hejtmánková, JŽ Suchanová… - International Journal of …, 2020 - Elsevier
Viral nanoparticles represent potential natural versatile platforms for targeted gene and drug
delivery. Improving the efficiency of gene transfer mediated by viral vectors could not only …

Application of cell penetrating peptides as a Promising drug carrier to combat viral infections

N Khairkhah, A Namvar, A Bolhassani - Molecular Biotechnology, 2023 - Springer
Novel effective drugs or therapeutic vaccines have been already developed to eradicate
viral infections. Some non-viral carriers have been used for effective drug delivery to a target …

Therapeutic delivery using cell-penetrating peptides

RR Sawant, NR Patel, VP Torchilin - European Journal of …, 2013 - degruyter.com
Intracellular delivery of promising therapeutic agents as well as nanocarriers presents a
unique challenge. However, with the discovery of the cell-penetrating peptides (CPPs) …